Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India.
J Endourol. 2010 Feb;24(2):191-8. doi: 10.1089/end.2009.0516.
Ureteral stents find wide application in urology. The majority of patients with indwelling ureteral stents are at an increased risk of urinary tract infection. Stent encrustation and its associated complications lead to significant morbidity. This review critically evaluates various polymers that find their application as ureteral stents with regard to various issues such as encrustation, bacterial colonization, urinary tract infections, and related clinical issues. A complete literature survey was performed, and all the relevant articles were scrutinized thoroughly. We discuss issues of encrustation/biofilm formation, new approaches to their testing, polymers currently available for use, new biomaterials, coatings, and novel ureteral stent designs, thereby providing a complete update on recent advances in the development of stents. Finally, we discuss the future of biomaterial use in the urinary tract.
输尿管支架在泌尿科中有广泛的应用。大多数留置输尿管支架的患者都存在尿路感 染的风险增加。支架结壳及其相关并发症会导致严重的发病率。本综述批判性地评估了各种聚 合物,这些聚合物作为输尿管支架在各种问题方面都有应用,例如结壳、细菌定植、尿路感染 和相关的临床问题。进行了全面的文献调查,并仔细审查了所有相关文章。我们讨论了结壳/ 生物膜形成的问题、对其进行测试的新方法、目前可用于使用的聚合物、新型生物材料、涂层和 新型输尿管支架设计,从而提供了支架开发方面的最新进展的全面更新。最后,我们讨论了生 物材料在泌尿道中的未来应用。