Galectin-3 在肾肿瘤中的表达：一种诊断、可能的预后标志物。
Expression of Galectin-3 in renal neoplasms: a diagnostic, possible prognostic marker.
机构信息
Department of Pathology, The Methodist Hospital and Research Institute and Weill Medical College of Cornell University, Houston, Texas, USA.
出版信息
Arch Pathol Lab Med. 2010 Jan;134(1):90-4. doi: 10.5858/2008-0392-OAR1.1.
CONTEXT
Galectin-3, a member of the lectin family, was shown to be expressed in normal distal tubular cells and in renal cell carcinomas (RCC). However, its diagnostic and prognostic significance in RCC is as yet undefined.
OBJECTIVES
To describe the expression of Galectin-3 among different histologic subtypes of renal neoplasms and to determine their diagnostic and prognostic significances.
DESIGN
The expression of Galectin-3 was evaluated in 217 renal neoplasms by tissue microarray and immunohistochemistry with semiquantitative analysis.
RESULTS
Strong expression of Galectin-3 was observed in 92 of 217 of renal neoplasms (42.4%). Although 22 of 23 oncocytomas (95.7%) and 19 of 21 chromophobe RCCs (90.5%) express Galectin-3, only 4 of 32 papillary RCCs (12.5%) and 47 of 137 clear cell RCCs (34.3%) express Galectin-3, suggesting that it may be used as a potential diagnostic marker. Galectin-3 expression was seen in 55% of high-grade (Fuhrman nuclear grades 3 and 4) versus 21% low-grade (grades 1 and 2) clear cell RCCs (P < .001).
CONCLUSIONS
This study confirms that Galactin-3 is strongly overexpressed in renal cell neoplasms of distal tubular differentiation, that is, oncocytoma and chromophobe RCCs, suggesting it might be used as a possible differential diagnostic tool for renal cell neoplasm with oncocytic or granular cells. Furthermore, we observed a strong association of overexpression of Galectin-3 and high nuclear grade in clear cell RCC. These results also suggest a possible pivotal role for Galectin-3 in the differentiation and prognosis of clear cell RCC.
背景
半乳糖凝集素-3 是凝集素家族的一员，已被证明在正常远端管状细胞和肾细胞癌 (RCC) 中表达。然而，其在 RCC 中的诊断和预后意义尚未确定。
目的
描述半乳糖凝集素-3 在不同组织学亚型肾肿瘤中的表达，并确定其诊断和预后意义。
设计
通过组织微阵列和免疫组织化学半定量分析评估 217 例肾肿瘤中半乳糖凝集素-3 的表达。
结果
在 217 例肾肿瘤中，有 92 例（42.4%）观察到半乳糖凝集素-3 的强表达。虽然 23 例嗜酸细胞瘤中的 22 例（95.7%）和 21 例嫌色细胞 RCC 中的 19 例（90.5%）表达半乳糖凝集素-3，但只有 32 例乳头状 RCC 中的 4 例（12.5%）和 137 例透明细胞 RCC 中的 47 例（34.3%）表达半乳糖凝集素-3，表明其可用作潜在的诊断标志物。半乳糖凝集素-3 的表达见于 55%的高级别（Fuhrman 核分级 3 和 4）与 21%的低级别（分级 1 和 2）透明细胞 RCC（P<0.001）。
结论
本研究证实，半乳糖凝集素-3在远端管状分化的肾肿瘤中过表达，即嗜酸细胞瘤和嫌色细胞 RCC，表明其可能用作肾肿瘤的可能鉴别诊断工具，这些肿瘤具有嗜酸细胞或颗粒细胞。此外，我们观察到半乳糖凝集素-3的过表达与透明细胞 RCC 的核高级别之间存在强烈关联。这些结果还表明半乳糖凝集素-3在透明细胞 RCC 的分化和预后中可能发挥关键作用。
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