Wang Jieti, Liu Yidong, Yang Yuanfeng, Xu Zhiying, Zhang Guodong, Liu Zheng, Fu Hangcheng, Wang Zewei, Liu Haiou, Xu Jiejie
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Oncotarget. 2016 Jul 5;7(27):41986-41995. doi: 10.18632/oncotarget.9749.
Galectin-7, has a controversial role in tumor progression, can either suppress tumor growth or induce chemoresistance depends on different tumor histology types. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery.
High galectin-7 expression was specifically correlated with necrosis (P = 0.015). Multivariate analysis confirmed galectin-7 as an independent prognosticator for OS (P = 0.005). High galectin-7 expression suggested poor OS (P < 0.001), particularly with UISS intermediate and high score groups. Notably, the predictive accuracy of the traditional prognostic scores was improved when combined with galectin-7 expression.
We retrospectively enrolled 416 patients who underwent nephrectomy at a single institute between 2008 and 2009 and detected their intratumor galectin-7 expression by immunohistochemistry. Kaplan-Meier method was conducted to plot survival curves and multivariate cox regression analysis for potential independent prognostic factors on OS. A nomogram was constructed with concordance index (C-index) and Akaike's Information Criteria (AIC) to appraise prognostic accuracy of different models.
High galectin-7 expression is an independent adverse predictor for survival. Evaluation of galectin-7 could help guide postsurgical management for non-metastatic ccRCC patients.
半乳糖凝集素-7在肿瘤进展中具有争议性作用，根据不同肿瘤组织学类型，它既可以抑制肿瘤生长，也可以诱导化疗耐药。本研究旨在评估半乳糖凝集素-7表达对非转移性透明细胞肾细胞癌（ccRCC）患者术后总生存期（OS）的影响。
高半乳糖凝集素-7表达与坏死显著相关（P = 0.015）。多因素分析证实半乳糖凝集素-7是OS的独立预后因素（P = 0.005）。高半乳糖凝集素-7表达提示OS较差（P < 0.001），尤其是在UISS中高分人群中。值得注意的是，当与半乳糖凝集素-7表达相结合时，传统预后评分的预测准确性得到了提高。
我们回顾性纳入了2008年至2009年间在单一机构接受肾切除术的416例患者，并通过免疫组织化学检测其肿瘤内半乳糖凝集素-7的表达。采用Kaplan-Meier法绘制生存曲线，并进行多因素Cox回归分析以确定OS的潜在独立预后因素。构建了具有一致性指数（C-index）和赤池信息准则（AIC）的列线图，以评估不同模型的预后准确性。
高半乳糖凝集素-7表达是生存的独立不良预后因素。评估半乳糖凝集素-7有助于指导非转移性ccRCC患者的术后管理。
