Department of Pathology, Saint Louis University, 1402 S Grand Blvd, St Louis, MO 63104, USA.
Arch Pathol Lab Med. 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130.
Gene microarray profiling of human breast carcinomas has recently categorized invasive breast carcinomas into 5 distinct subtypes; luminal A, luminal B, normal breastlike, human epithelial growth factor receptor 2 (HER2) overexpressing, and basal-like. Basal-like breast carcinomas are characterized by high expression of basal cytokeratins; low or absent expression of estrogen receptor, progesterone receptor, and HER2/neu; and expression of epidermal growth factor receptor (EGFR) and/or c-kit, and they are frequently associated with breast cancer 1 (BRCA1) mutations and poor clinical outcome. Recent studies have begun to provide insights into the molecular genetics, biology, morphology, and clinical outcome of this subtype of breast carcinoma. We reviewed the literature related to basal-like breast carcinomas to better understand this clinically significant subtype of breast carcinoma.
最近，对人类乳腺癌的基因微阵列分析将浸润性乳腺癌分为 5 个不同亚型：腔 A 型、腔 B 型、正常乳腺样型、人表皮生长因子受体 2（HER2）过表达型和基底样型。基底样乳腺癌的特征是基底细胞角蛋白高表达；雌激素受体、孕激素受体和 HER2/neu 低表达或缺失；表皮生长因子受体（EGFR）和/或 c-kit 表达，并且它们常与乳腺癌 1（BRCA1）突变和不良临床结局相关。最近的研究开始提供有关这种乳腺癌亚型的分子遗传学、生物学、形态学和临床结局的见解。我们回顾了与基底样乳腺癌相关的文献，以更好地了解这种具有临床意义的乳腺癌亚型。
