Institut de Biologia Molecular de Barcelona, CSIC, Barcelona Scientific Park, Baldiri i Reixac 15-21, 08028 Barcelona, Spain.
Biochem Soc Trans. 2010 Feb;38(Pt 1):21-8. doi: 10.1042/BST0380021.
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism. Recent work, reviewed in the present paper, provides new perspective on the widening influence of Dubs and a new tool to focus studies of not only Dub interactions, but also potentially many more cellular systems.
去泛素化是泛素介导的信号网络中的一个关键机制。随着新的作用被阐明，新的途径被证明受到这一机制的影响，Dubs（去泛素化酶）作为各种细胞过程的调节剂的重要性变得越来越明显。本文综述了最近的工作，为 Dubs 日益扩大的影响提供了新的视角，并为研究 Dub 相互作用以及可能更多的细胞系统提供了新的工具。
