School of Biological and Biomedical Sciences, Durham University, Sciences Laboratories, South Road, Durham DH1 3LE, UK.
Biochem Soc Trans. 2010 Feb;38(Pt 1):273-7. doi: 10.1042/BST0380273.
Eukaryotic cells have developed a series of highly controlled processes of transport between the nucleus and cytoplasm. The present review focuses on the latest advances in our understanding of nucleocytoplasmic exchange of molecules in yeast, a widely studied model organism in the field. It concentrates on the role of individual proteins such as nucleoporins and karyopherins in the translocation process and relates this to how the organization of the nuclear pore complex effectively facilitates the bidirectional transport between the two compartments.
真核细胞已经发展出一系列高度受控的核质运输过程。本综述重点介绍了我们在酵母中对分子核质交换的最新理解进展，酵母是该领域广泛研究的模式生物。它集中于核孔蛋白和核转运蛋白等个别蛋白质在易位过程中的作用，并将其与核孔复合体的组织如何有效地促进两个隔室之间的双向运输联系起来。
