Center for Cancer Research, Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
Ann N Y Acad Sci. 2009 Dec;1182:69-79. doi: 10.1111/j.1749-6632.2009.05069.x.
Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.
干扰素γ（IFN-γ）是一种多功能细胞因子，对几乎所有免疫细胞以及先天免疫和适应性免疫反应的功能都很重要。1986 年，开始对这种细胞因子进行早期临床试验，以评估其治疗潜力。最初的研究集中在 IFN-γ的耐受性和药理学上，并系统地确定了其抗肿瘤和抗感染活性。自首次临床试验以来的 20 多年中，IFN-γ已被广泛用于各种临床适应证，本文对此进行了综述。
