Furudate S
Department of Laboratory Animal Science, Kitasato University School of Medicine, Kanagawa, Japan.
Jikken Dobutsu. 1991 Jan;40(1):77-82. doi: 10.1538/expanim1978.40.1_77.
In pseudopregnancy of the rat prolactin (PRL) is released in the form of twice daily surges (nocturnal and diurnal surges). An attempt was made to examine the effects of urethane anesthesia on PRL surges during pseudopregnancy of the rat. In a preliminary study, using the continuous blood sampling method, the nocturnal PRL surge was completely blocked when urethane (1.0g/kg BW) was administered at 0:00 hr. Urethane (1.0g/kg BW) was injected at 0:00 or 12:00 hr, and serum and pituitary PRL concentrations were measured at 6:00 or 18:00 hr, respectively, to study the effects of urethane on nocturnal or diurnal PRL surges. There were no serum PRL surges during either the nocturnal or diurnal periods following urethane injection. The experiment examining pituitary PRL concentration at 6:00 or 18:00 hr confirmed that urethane (1.0g/kg) anesthesia suppressed the release of PRL surge from the pituitary.
在大鼠假孕期间，催乳素（PRL）以每日两次高峰（夜间高峰和日间高峰）的形式释放。本研究旨在探讨氨基甲酸乙酯麻醉对大鼠假孕期间PRL高峰的影响。在一项初步研究中，采用连续采血法，当在0:00时给予氨基甲酸乙酯（1.0g/kg体重）时，夜间PRL高峰被完全阻断。分别在0:00或12:00时注射氨基甲酸乙酯（1.0g/kg体重），并分别在6:00或18:00时测量血清和垂体PRL浓度，以研究氨基甲酸乙酯对夜间或日间PRL高峰的影响。注射氨基甲酸乙酯后，夜间或日间均未出现血清PRL高峰。在6:00或18:00时检测垂体PRL浓度的实验证实，氨基甲酸乙酯（1.0g/kg）麻醉抑制了垂体PRL高峰的释放。
