卵巢癌中核DNA含量与类固醇受体状态之间的相关性

Correlation between nuclear DNA content and steroid receptor status in ovarian cancer.

作者信息

Slotman B J, Baak J P, Rao B R

机构信息

Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1991 Feb 25;38(3):221-7. doi: 10.1016/0028-2243(91)90296-w.

DOI:10.1016/0028-2243(91)90296-w

PMID:2007449

Abstract

The nuclear DNA content of 47 malignant epithelial ovarian tumours and five ovarian tumours of borderline malignancy was correlated with estrogen (ER), progesterone (PR) and androgen receptor (AR) status. Aneuploidy was observed in 60% of the malignant tumours. The DNA index of poorly differentiated tumours was higher than that of well differentiated tumours (P less than 0.05). Ploidy did not correlate with histological type, stage of disease and ER content. Of the diploid tumours, 74% was PR-positive, in contrast to 36% of the aneuploid tumours (P less than 0.05). In addition, 89% of the diploid tumours had high AR levels (greater than or equal to 30 fmol/mg cytosol protein), in contrast to only 54% of the aneuploid tumours (P less than 0.05). These observations strengthen our previous findings on the prognostic importance of PR and also suggest that androgens may have a role in ovarian cancer.

摘要

对47例恶性上皮性卵巢肿瘤和5例交界性恶性卵巢肿瘤的核DNA含量与雌激素（ER）、孕激素（PR）及雄激素受体（AR）状态进行相关性分析。60%的恶性肿瘤存在非整倍体现象。低分化肿瘤的DNA指数高于高分化肿瘤（P<0.05）。倍体与组织学类型、疾病分期及ER含量无关。二倍体肿瘤中74%为PR阳性，而异倍体肿瘤中这一比例为36%（P<0.05）。此外，89%的二倍体肿瘤AR水平较高（≥30 fmol/mg胞浆蛋白），而异倍体肿瘤中仅54%如此（P<0.05）。这些观察结果强化了我们之前关于PR预后重要性的发现，也提示雄激素可能在卵巢癌中发挥作用。