Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G-14, Atlanta, GA 30333, USA.
Mol Phylogenet Evol. 2010 Jun;55(3):1103-10. doi: 10.1016/j.ympev.2010.01.006. Epub 2010 Jan 13.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne RNA virus responsible for outbreaks of severe hemorrhagic fever in humans. Although CCHF was first detected in the 1940s, high levels of genomic diversity argue against a recent origin. Here, Bayesian coalescent analyses were used to estimate the rate of evolution and relative age of the virus. A total of 43 S, 34 M, and 23 L segment sequences from samples collected between 1956 and 2005 were analyzed from across the broad geographic range of the virus. Using a relaxed molecular clock model, nucleotide substitutions were estimated to have occurred at a rate of 1.09x10(-4), 1.52x10(-4), and 0.58x10(-4) substitutions/site/year for the S, M, and L segments, respectively. The most recent common ancestor of the viruses existed approximately 3100-3500 years before present, or around 1500-1100 BC. Changes in agricultural practices and climate occurring near the time of the most recent common ancestor of CCHFV may have contributed to its emergence and spread.
克里米亚-刚果出血热（CCHF）是一种由蜱传播的 RNA 病毒，可导致人类严重出血热的爆发。尽管 CCHF 于 20 世纪 40 年代首次被发现，但高基因组多样性表明它并非最近才出现的。在此，我们使用贝叶斯系统发育分析来估计病毒的进化速度和相对年龄。总共分析了来自 1956 年至 2005 年之间采集的样本的 43 个 S、34 个 M 和 23 个 L 节段序列，这些样本来自病毒广泛的地理分布范围。使用宽松的分子钟模型，估计 S、M 和 L 节段的核苷酸替换率分别为 1.09x10(-4)、1.52x10(-4)和 0.58x10(-4)替换/位点/年。病毒的最近共同祖先大约存在于 3100-3500 年前，或公元前 1500-1100 年左右。CCHFV 最近共同祖先时期发生的农业实践和气候变化的变化可能促成了其出现和传播。
