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Ⅰ期 Norwood 手术:优化的技术操作表现改善了预后,而与术前生理状态或病例复杂性无关。

Stage I Norwood: optimal technical performance improves outcomes irrespective of preoperative physiologic status or case complexity.

机构信息

Department of Cardiac Surgery, Children's Hospital Boston, Boston, Mass; Harvard Medical School, Boston, MA 02115, USA.

出版信息

J Thorac Cardiovasc Surg. 2010 Apr;139(4):962-8. doi: 10.1016/j.jtcvs.2009.10.011. Epub 2010 Jan 13.

Abstract

OBJECTIVE

Interplay of baseline physiologic status, case complexity, technical performance, and outcomes in high-acuity operations has been poorly defined. This study explored these interactions to determine whether a technically optimal operation can mitigate effects of baseline physiology and high case-complexity on outcomes for the stage I Norwood procedure.

METHODS

Technical performance was categorized as optimal, adequate, or inadequate from adequacy of the anatomic repair of the stage I subprocedures according to anatomic areas where intervention is performed. Physiological illness severity statuses in preoperative and postoperative periods were determined with Pediatric Risk of Mortality III system, which uses 17 physiologic variables. Case complexity was calculated with Aristotle comprehensive system. All patients undergoing stage I procedure from January 2004 to December 2007 were retrospectively studied.

RESULTS

One hundred thirty-five procedures were included. Five were excluded from the technical performance assessment because of inadequate postoperative data. Eighty-one (62.3%), 26 (20%), and 23 (17.7%), respectively, were scored as optimal, adequate, and inadequate. Overall hospital mortality was 14.1%. Inadequate technical performance, high-complexity Aristotle comprehensive scores, and high preoperative illness severity scores correlated with significantly higher hospital mortality, longer stay, and greater frequency of major postoperative complications. In subgroup analysis of patients with optimal technical performance, outcomes were favorable irrespective of high or low preoperative physiologic illness severity or case complexity.

CONCLUSIONS

In stage I Norwood procedures, optimal technical performance attenuated effects of poor preoperative physiologic status and high case complexity, with reduced hospital mortality. Inadequate technical performance resulted in poor outcomes regardless of preoperative status.

摘要

目的

基础生理状态、病例复杂性、技术性能和高难度手术结果之间的相互作用尚未得到很好的定义。本研究探讨了这些相互作用,以确定在 I 期 Norwood 手术中,技术上优化的手术是否可以减轻基础生理状况和高病例复杂性对结果的影响。

方法

根据进行干预的解剖区域,将 I 期亚手术的解剖修复的充分性分为技术性能为优化、充分和不足。使用包含 17 个生理变量的儿科死亡率 III 系统来确定术前和术后的生理疾病严重程度状态。使用亚里士多德综合系统来计算病例复杂性。回顾性研究了 2004 年 1 月至 2007 年 12 月期间接受 I 期手术的所有患者。

结果

共纳入 135 例手术。由于术后数据不足,有 5 例手术未纳入技术性能评估。分别有 81(62.3%)、26(20%)和 23(17.7%)例手术的技术性能评为优化、充分和不足。总的住院死亡率为 14.1%。技术性能不足、高复杂性亚里士多德综合评分和高术前疾病严重程度评分与显著较高的住院死亡率、较长的住院时间和更高的术后主要并发症发生率相关。在技术性能优化的患者亚组分析中,无论术前生理疾病严重程度或病例复杂性高低,结果均良好。

结论

在 I 期 Norwood 手术中,优化的技术性能减轻了较差的术前生理状态和高病例复杂性的影响,降低了住院死亡率。技术性能不足导致预后不良,无论术前状态如何。

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