Department of Mathematics, Zhejiang University, Hangzhou, P. R. China.
AJNR Am J Neuroradiol. 2010 Jun;31(6):1063-7. doi: 10.3174/ajnr.A1984. Epub 2010 Jan 14.
MR is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behavior. With a 2D region of interest-based GI, a preliminary study reported significantly reduced gyrification in the prefrontal lobe in MR. The purpose of this study was to further investigate the abnormalities of cortical gyrification in MR and to explore the possible causes of these abnormalities.
Thirteen patients with MR and 26 demographically matched healthy controls were included in this study. A 3D surface-based lGI was calculated as a measure to quantify gyrification. Then vertex-by-vertex contrasts of lGI were performed between patients with MR and healthy controls.
Statistical analysis showed that patients with MR had significantly reduced lGI in multiple brain regions compared with healthy controls. These regions include the lateral and medial prefrontal cortices, the right superior temporal gyrus, the left superior parietal lobe, the bilateral insular and adjacent cortices, and the visual and motor cortices.
The observed abnormal pattern of cortical gyrification revealed by significant reduction of lGI in multiple brain regions might reflect the developmental disturbance in intracortical organization and cortical connectivities in MR.
MR 是一种与认知功能障碍和适应行为缺陷相关的发育障碍。一项基于 2D 感兴趣区的 GI 的初步研究报告称，MR 患者的前额叶回脑回减少。本研究的目的是进一步研究 MR 患者脑回结构异常，并探讨这些异常的可能原因。
本研究纳入了 13 名 MR 患者和 26 名年龄匹配的健康对照者。采用基于 3D 表面的 lGI 作为量化脑回结构的指标。然后对 MR 患者和健康对照组的脑区进行 lGI 顶点对顶点对比。
统计分析显示，与健康对照组相比，MR 患者多个脑区的 lGI 明显减少。这些脑区包括外侧和内侧前额叶皮质、右侧颞上回、左侧顶上叶、双侧岛叶及相邻皮质、视觉和运动皮质。
多个脑区 lGI 显著减少所揭示的脑回结构异常模式可能反映了 MR 患者皮质内组织和皮质连接发育障碍。
