Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental disorders (Xiangya), Changsha, Hunan 410011, China.
J Affect Disord. 2019 Nov 1;258:1-10. doi: 10.1016/j.jad.2019.07.065. Epub 2019 Jul 30.
The high recurrence of major depressive disorder (MDD) may derive from underlying state-independent structural alterations.
First-episode drug-naïve currently depressed (cMDD) patients (N = 97), remitted depressed (RD) patients (N = 72), and healthy controls (HCs, N = 100) underwent structural magnetic resonance imaging (MRI). Group differences in cortical thickness (CT), surface area (SA), and local gyrification index (lGI) were analyzed in FreeSurfer.
Both groups of depressed patients had significantly decreased CT, relative to HCs, in the left precentral gyrus and significantly increased lGI values in the left superior frontal gyrus (SFG) indicative of state-independent alterations. Relative to HCs, the cMDD group had decreased CT of the SFG, caudal middle frontal gyrus (MFG), posterior cingulate cortex (PCC), and lateral occipital regions as well as increased SA or lGI of the superior temporal gyrus, precuneus, and pericalcarine, whereas the RD group had increased SA or lGI of the SFG, caudal MFG, and supramarginal gyrus; these alterations appeared to be state-dependent. SA or lGI values of the fusiform gyrus, inferior temporal gyrus, and superior parietal lobule differed between the cMDD and RD groups, consistent with state-dependent alterations. Beck depression inventory scores correlated with CT or lGI values of the caudal MFG, lateral occipital cortex in depressed patients.
The structural features of several subcortical limbic regions were not analyzed.
Left precentral gyrus CT and left SFG gyrification alterations may represent state-independent alterations in MDD.
重度抑郁症（MDD）的高复发率可能源于潜在的与状态无关的结构改变。
首次发作、未经药物治疗、目前抑郁（cMDD）患者（N=97）、缓解抑郁（RD）患者（N=72）和健康对照（HCs，N=100）接受了结构磁共振成像（MRI）检查。在 FreeSurfer 中分析了皮质厚度（CT）、表面积（SA）和局部回环指数（lGI）的组间差异。
与 HCs 相比，两组抑郁患者的左侧中央前回 CT 均显著降低，左侧额上回 lGI 值显著升高，表明存在与状态无关的改变。与 HCs 相比，cMDD 组的额上回、额中回下部、后扣带回和外侧枕叶的 CT 降低，颞上回、楔前叶和距状回的 SA 或 lGI 增加，而 RD 组的额上回、额中回下部和缘上回的 SA 或 lGI 增加；这些改变似乎是状态依赖性的。梭状回、颞下回和顶下小叶的 SA 或 lGI 值在 cMDD 和 RD 组之间存在差异，与状态依赖性改变一致。抑郁患者的 Beck 抑郁量表评分与额中回下部、外侧枕叶的 CT 或 lGI 值相关。
未分析几个皮质下边缘区域的结构特征。
左侧中央前回 CT 和左侧额上回回环改变可能代表 MDD 的与状态无关的改变。
