Kamara Nicholas Thadeus, Asiimwe Stephen
Mbarara University of Science and Technology, P O Box 1410, Mbarara, Uganda.
Trop Doct. 2010 Jan;40(1):41-2. doi: 10.1258/td.2009.090086.
Dyslipidaemia and hypertension in patients with diabetes increase the risk of macrovascular and microvascular complications. We took anthropometric measurements, lipids, blood pressure and fasting blood sugar of 150 diabetics and 151 non-diabetics. Among the diabetics, 17 (11.3%) had total cholesterol (TC) > or =200 mg/dL, 70 (46.6%) had triglycerides (TG) > or =150 mg/dL, 78 (52%) had high density lipoprotein (HDL) < or =40 mg/dL and 26 (17.3%) had low density lipoprotein (LDL) > or =100 mg/dL. Diabetics were more likely to have raised TG, OR = 1.88 (95% CI 1.17 - 3.00), P = 0.01; high systolic blood pressure (SBP), OR= 3.22 (95% CI 1.86 - 5.59), P = 0.01; and high diastolic blood pressure (DBP) OR = 4.11(95% CI 1.86 - 5.59), P = 0.01. The prevalence of HDL and TG dyslipidaemia among the diabetics in Uganda is significantly higher than in non-diabetics, as is the prevalence of systolic and diastolic hypertension. Other studies need to be done to assess the effect of lipids on cardiovascular disease, mortality and morbidity in diabetic patients in Uganda.
糖尿病患者的血脂异常和高血压会增加大血管和微血管并发症的风险。我们对150名糖尿病患者和151名非糖尿病患者进行了人体测量、血脂、血压和空腹血糖检测。在糖尿病患者中,17例(11.3%)总胆固醇(TC)≥200mg/dL,70例(46.6%)甘油三酯(TG)≥150mg/dL,78例(52%)高密度脂蛋白(HDL)≤40mg/dL,26例(17.3%)低密度脂蛋白(LDL)≥100mg/dL。糖尿病患者更易出现TG升高,比值比(OR)=1.88(95%置信区间[CI]1.17 - 3.00),P = 0.01;收缩压(SBP)升高,OR = 3.22(95%CI 1.86 - 5.59),P = 0.01;舒张压(DBP)升高,OR = 4.11(95%CI 1.86 - 5.59),P = 0.01。乌干达糖尿病患者中HDL和TG血脂异常的患病率显著高于非糖尿病患者,收缩期和舒张期高血压的患病率也是如此。需要开展其他研究来评估血脂对乌干达糖尿病患者心血管疾病、死亡率和发病率的影响。