脂联素和炎症生物标志物在 2 型糖尿病中的临床意义。
Clinical implications of adiponectin and inflammatory biomarkers in type 2 diabetes mellitus.
机构信息
Department of Biochemistry, National Research Center, Dokki, Giza, Egypt.
出版信息
Dis Markers. 2009;27(6):269-78. doi: 10.3233/DMA-2009-0672.
OBJECTIVES
To study the interrelationships of adiponectin, C-reactive protein (CRP) and fibrinogen with each other in T2DM patients with (T2DM-C) and without complications (T2DM-NC) among healthy individuals.
DESIGN AND METHODS
The study comprised of 120 T2DM-C, 59 T2DM-NC patients and 40 healthy volunteers. Biochemical markers were determined in the serum.
RESULTS
Positivity rates of CRP and fibrinogen were significantly increased in T2DM-C as compared to T2DM-NC or controls, whereas adiponectin showed highest level in healthy individuals. Inflammatory biomarkers were inversely correlated with adiponectin (P< 0.01). Lipid profiles, kidney functions and BMI, showed positive significant correlation with CRP and fibrinogen but negative correlation with adiponectin. For better detection of T2DM, the combined sensitivity (98.9%) and specificity (92.5%) of fibrinogen and adiponectin was higher than the combined sensitivity and specificity of fibrinogen and CRP or adiponectin and CRP or than that of the biomarkers alone.
CONCLUSION
Elevated levels of CRP and fibrinogen and reduced level of adiponectin can be used for early diagnosis of T2DM and can predict diabetic complications.
目的
研究 2 型糖尿病患者（T2DM-C）与无并发症的 2 型糖尿病患者（T2DM-NC）和健康个体之间脂联素、C 反应蛋白（CRP）和纤维蛋白原之间的相互关系。
设计和方法
本研究包括 120 例 T2DM-C 患者、59 例 T2DM-NC 患者和 40 名健康志愿者。检测血清中的生化标志物。
结果
与 T2DM-NC 或对照组相比，T2DM-C 患者的 CRP 和纤维蛋白原阳性率显著升高，而脂联素在健康个体中水平最高。炎症生物标志物与脂联素呈负相关（P<0.01）。脂代谢谱、肾功能和 BMI 与 CRP 和纤维蛋白原呈正相关，与脂联素呈负相关。为了更好地检测 2 型糖尿病，纤维蛋白原和脂联素的联合敏感性（98.9%）和特异性（92.5%）高于纤维蛋白原和 CRP 或脂联素和 CRP 的联合敏感性和特异性，也高于单独使用这些生物标志物的敏感性和特异性。
结论
CRP 和纤维蛋白原水平升高，脂联素水平降低可用于 2 型糖尿病的早期诊断，并可预测糖尿病并发症。
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