Sarangi Rajlaxmi, Padhi Somanath, Mohapatra Srikrushna, Swain Sarmistha, Padhy Rashmita K, Mandal Manmath K, Patro Saurav K, Kumar Shambhu
Department of Biochemistry, Pondicherry Institute of Medical Sciences, Ganapathychettykulam, Kalapet, Puducherry, India.
Diabetes Metab Syndr. 2012 Jan-Mar;6(1):9-14. doi: 10.1016/j.dsx.2012.05.015. Epub 2012 Jun 7.
Inflammation is postulated to play a role in diabetogenesis and its further vascular complications. The aim was to assess the inflammatory and lipid parameters in patients of type 2 diabetic mellitus with or without complication.
Serum high sensitivity C-reactive protein (hs-CRP), nitric oxide metabolite (NO(X)), fibrinogen, and lipid parameters were measured in eighty type 2 diabetic males (40-65 years) without (n=40, group B) and with complication (16 retinopathy, group C; 24 hypertension, group D); and compared with 40 healthy, age and sex matched nondiabetic males (group A) from the general population.
The mean age of subjects and fasting plasma glucose among groups A, B, and C+D were 51.0 ± 7.1 vs. 48.7 ± 5.7 vs. 50.2 ± 6.1 years (p>0.05); and 96.7 ± 10.4 vs. 134.3 ± 27.8 vs. 136.4 ± 29.8 mg/dl (p<0.001) respectively. Patients with retinopathy were older, with longer duration of diabetes, and high fasting plasma glucose (p<0.001). The mean hs-CRP, NO(X), fibrinogen, TC, TG, and LDL(C) varied significantly (p<0.001) between control and diabetics. hs-CRP, NO(X), and fibrinogen were found to be highest in retinopathy group whereas no significant (p>0.05) difference was noted between groups B and D in relation to hs-CRP and NO(X). TC and LDL(C) were significantly (p<0.001) high among group B patients. Significant positive correlation was observed between all three inflammatory markers in all categories of patients; between FPG, hs-CRP, and fibrinogen among patients with hypertension; between FPG, hs-CRP, and NO(X) in patients with retinopathy. However, none of the lipid parameters showed any significant correlation with any of the inflammatory markers in any group of patients studied.
Low grade systemic inflammation, in association with dyslipidemia, plays a role in diabetogenesis and its complications.
据推测，炎症在糖尿病发生及其进一步的血管并发症中起作用。本研究旨在评估有无并发症的2型糖尿病患者的炎症和血脂参数。
对80名年龄在40 - 65岁之间的2型糖尿病男性患者进行血清高敏C反应蛋白（hs-CRP）、一氧化氮代谢产物（NO(X)）、纤维蛋白原和血脂参数检测，其中无并发症者（n = 40，B组），有并发症者（16例视网膜病变，C组；24例高血压，D组）；并与40名来自普通人群的年龄、性别匹配的健康非糖尿病男性（A组）进行比较。
A组、B组以及C + D组受试者的平均年龄分别为51.0 ± 7.1岁、48.7 ± 5.7岁、50.2 ± 6.1岁（p > 0.05）；空腹血糖分别为96.7 ± 10.4mg/dl、134.3 ± 27.8mg/dl、136.4 ± 29.8mg/dl（p < 0.001）。视网膜病变患者年龄更大，糖尿病病程更长，空腹血糖更高（p < 0.001）。对照组与糖尿病组之间，hs-CRP、NO(X)、纤维蛋白原、总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL(C)）的均值差异有统计学意义（p < 0.001）。视网膜病变组的hs-CRP、NO(X)和纤维蛋白原最高，而B组和D组在hs-CRP和NO(X)方面无显著差异（p > 0.05）。B组患者的TC和LDL(C)显著升高（p < 0.001）。在所有类型的患者中，三种炎症标志物之间均观察到显著正相关；高血压患者的空腹血糖（FPG）、hs-CRP和纤维蛋白原之间；视网膜病变患者的FPG、hs-CRP和NO(X)之间。然而，在所研究的任何一组患者中，血脂参数与任何炎症标志物均无显著相关性。
低度全身炎症与血脂异常共同在糖尿病发生及其并发症中起作用。
