对P53和VEGF（血管内皮生长因子）进行免疫组织化学评估，对晚期食管腺癌的长期生存并无预后价值。
Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma.
作者信息
Cavazzola Leandro Totti, Rosa André Ricardo Pereira da, Schirmer Carlos Cauduro, Gurski Richard Ricachenevski, Telles João Pedro Bueno, Mielke Fernando, Meurer Luíse, Edelweiss Maria Isabel Albano, Kruel Cleber Dario Pinto
机构信息
Departamento de Patologia, UFRGS, RS, BR.
出版信息
Rev Col Bras Cir. 2009 Feb;36(1):24-34. doi: 10.1590/s0100-69912009000100007.
OBJECTIVES
To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma.
METHODS
Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively.
RESULTS
P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival.
CONCLUSION
The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.
目的
将p53蛋白和血管内皮生长因子（VEGF）的表达与接受根治性切除治疗的食管腺癌患者的预后相关联。
方法
研究了46例接受根治性切除的食管腺癌患者。分别通过免疫组织化学评估了52.2%的肿瘤中p53蛋白的表达和47.8%的肿瘤中VEGF的表达。
结果
26%的病例中p53蛋白和VEGF表达一致，且未观察到这些表达之间存在相关性。没有临床病理因素与p53蛋白或VEGF表达显示出显著相关性。p53蛋白和VEGF表达与长期生存之间没有显著关联。
结论
在接受根治性切除的食管腺癌患者中，p53蛋白和VEGF的表达与预后无关。
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