4,4'-二甲基胆甾-7,9,14-三烯醇是二氢鹅去氧胆甾醇脱甲基化过程中的一种中间体。
4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol.
作者信息
Tavares I A, Munday K A, Wilton D C
出版信息
Biochem J. 1977 Jul 15;166(1):17-20. doi: 10.1042/bj1660017.
Abstract
- 4,4'-Dimethylcholesta-7,9,14-trienol is an intermediate in the metabolism of dihydroagnosterol to cholesterol by rat liver homogenate. 2. This triene is reduced by a rat liver microsomal preparation in the presence of NADPH to give 4,4'-dimethylcholesta-7,9-dienol under anaerobic conditions. 3. Reduction of the triene in the presence of [4-3H2]NADPH resulted in the incorporation of 3H into the product. 4. Under aerobic conditions the triene is converted into cholesterol by a rat liver homogenate.
摘要
- 4,4'-二甲基胆甾-7,9,14-三烯醇是大鼠肝脏匀浆将二氢麦角甾醇代谢为胆固醇过程中的一种中间体。2. 在厌氧条件下，这种三烯在大鼠肝脏微粒体制剂存在及NADPH存在的情况下被还原，生成4,4'-二甲基胆甾-7,9-二烯醇。3. 在[4-³H₂]NADPH存在的情况下还原该三烯，导致³H掺入产物中。4. 在有氧条件下，该三烯被大鼠肝脏匀浆转化为胆固醇。
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