大鼠肝脏中双氢阿格诺甾醇转化为胆固醇的途径。
The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver.
作者信息
Tavares I A, Munday K A, Wilton D C
出版信息
Biochem J. 1977 Jul 15;166(1):11-5. doi: 10.1042/bj1660011.
Abstract
Dihydroagnosterol is demethylated by a rat liver homogenate to give 4,4'-dimethylcholesta 7,9-dienol and then cholesta-7,9-dienol. The cholesta-7,9-dienol is isomerized to cholesta-8,14-dienol, which is converted into cholesterol by the normal pathway.
摘要
二氢阿格诺甾醇被大鼠肝脏匀浆去甲基化，生成4,4'-二甲基胆甾-7,9-二烯醇，然后生成胆甾-7,9-二烯醇。胆甾-7,9-二烯醇异构化为胆甾-8,14-二烯醇，后者通过正常途径转化为胆固醇。
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本文引用的文献
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The conversion of cholest-7-en-3beta-ol into cholesterol. General comments on the mechanism of the introduction of double bonds in enzymic reactions.胆甾-7-烯-3β-醇转变为胆固醇。关于酶反应中双键引入机制的一般评述。
Biochem J. 1967 Dec;105(3):1187-94. doi: 10.1042/bj1051187.
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Biosynthesis of skin sterols. III. Conversion of squalene to sterols by rat skin.皮肤甾醇的生物合成。III. 大鼠皮肤将角鲨烯转化为甾醇的过程。
J Biol Chem. 1963 May;238:1643-55.
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Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite.异构4,4-二甲基胆甾烯醇的合成及羊毛甾醇代谢物的鉴定
J Biol Chem. 1958 Dec;233(6):1343-7.
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Biological synthesis of lanosterol and agnosterol.羊毛甾醇和鹅甾醇的生物合成。
J Biol Chem. 1956 Jan;218(1):305-18.
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Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium.新生儿和婴儿中的类固醇。人胎粪中酯化和游离类固醇中24,25-二氢-δ-9(11)-羊毛甾醇和4α,14α-二甲基取代类固醇的鉴定。
Eur J Biochem. 1969 Dec;11(3):456-64. doi: 10.1111/j.1432-1033.1969.tb00795.x.
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