Timko Denise M, Stickle Douglas F
Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA.
Methods Mol Biol. 2010;603:327-38. doi: 10.1007/978-1-60761-459-3_31.
The potential for adverse effects of lead (Pb) exposure on development in children remains a health concern in the U.S., and programmatic screening of children for elevated blood lead levels ([Pb] >10 microg/dL) is widespread. With sufficiently sensitive technology for the measurement of lead such as ICP-MS, it is possible to utilize filter paper bloodspots as a specimen suitable for lead screening. Filter paper bloodspot specimens are relatively inexpensive, easy to collect, and stable during transport. For these reasons they are preferred by many program clinics for child subjects. We describe measurement of Pb from filter paper bloodspots using ICP-MS and bloodspot standards.
在美国，铅（Pb）暴露对儿童发育产生不良影响的可能性仍是一个健康问题，并且对儿童进行血铅水平升高（[Pb]>10微克/分升）的计划性筛查很普遍。有了诸如电感耦合等离子体质谱仪（ICP-MS）这样足够灵敏的铅测量技术，就有可能将滤纸血斑用作适合铅筛查的标本。滤纸血斑标本相对便宜、易于采集且在运输过程中稳定。由于这些原因，许多项目诊所更倾向于将其用于儿童受试者。我们描述了使用ICP-MS和血斑标准品来测量滤纸血斑中的铅。
