Faubert Guillaume, Lebel Denis, Bussières Jean-François
Pharmacy Department, Pharmaceutical Practice Research Unit, CHU Sainte-Justine, 3175, Chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
Pharm World Sci. 2010 Apr;32(2):179-86. doi: 10.1007/s11096-010-9364-2. Epub 2010 Jan 14.
The aim of this article is to evaluate and compare two natural health product databases for the purpose of integrating them into a pharmacy information system in Canada.
This is a descriptive pilot study that compared the Natural Medicine Comprehensive Database (NMCD) and Natural Standard Database (NSD). We randomly chose five hospital patient files. For each drug prescription, we searched for and counted the number of potential natural health product-drug interactions in each database.
We compared all of the potential interactions between dexamethasone and the natural health products in both databases. We also evaluated the quality of a selection of references for 30 potential natural health product-dexamethasone interactions.
Five pediatric patient files were selected for a total of 21 different common names. The number of potential natural health product-drug interactions identified varied from 12 (salbutamol-albuterol) to 129 (dexamethasone) in the NSD for an average of 63 +/- 33. The number of potential natural health product-drug interactions identified varied from 1 (salbutamol-albuterol) to 96 (dexamethasone) in the NMCD for an average of 55 +/- 27. There was no significant difference between the average number of potential natural health product-drug interactions between the databases (P = 0.40). The average number of common potential interactions was 9 +/- 8. Thirty potential interactions of dexamethasone were compared. The number of abstracts per pair of interactions varied from 0 (Aloe-dexamethasone in the NSD) to 17 (dexamethasone-St. John's wort in the NMCD). For the 10 pairs that were common to both databases, the number of abstracts given was 4.5 +/- 4.7 for the NMCD and 3.1 +/- 2.1 for the NSD (P = 0.41) and the average evaluation score was 4.6 +/- 1.5 for the NMCD and 5.6 +/- 1.2 for the NSD (P = 0.43).
This pilot study presents a comparison of potential natural health product-drug interactions from two different databases using two different scenarios in a hospital setting. The study reveals a high and variable number of pairs of natural health product-drug interactions per drug between the NSD and the NMCD. Further studies are necessary to evaluate the pertinence and hierarchy of the information offered by suppliers and natural health product databases.
本文旨在评估和比较两个天然健康产品数据库，以便将它们整合到加拿大的药房信息系统中。
这是一项描述性试点研究，比较了天然药物综合数据库（NMCD）和天然标准数据库（NSD）。我们随机选择了五份医院患者档案。对于每份药物处方，我们在每个数据库中搜索并统计潜在的天然健康产品与药物相互作用的数量。
我们比较了两个数据库中地塞米松与天然健康产品之间的所有潜在相互作用。我们还评估了30种潜在的天然健康产品与地塞米松相互作用的参考文献质量。
选择了五份儿科患者档案，共有21种不同的通用名。在NSD中，识别出的潜在天然健康产品与药物相互作用的数量从12（沙丁胺醇 - 舒喘灵）到129（地塞米松）不等，平均为63±33。在NMCD中，识别出的潜在天然健康产品与药物相互作用的数量从1（沙丁胺醇 - 舒喘灵）到96（地塞米松）不等，平均为55±27。两个数据库之间潜在的天然健康产品与药物相互作用的平均数量没有显著差异（P = 0.40）。共同潜在相互作用的平均数量为9±8。比较了30种地塞米松的潜在相互作用。每对相互作用的摘要数量从0（NSD中的芦荟 - 地塞米松）到17（NMCD中的地塞米松 - 圣约翰草）不等。对于两个数据库共有的10对相互作用，NMCD给出的摘要数量为4.5±4.7，NSD为3.1±2.1（P = 0.41），NMCD的平均评估分数为4.6±1.5，NSD为5.6±1.2（P = 0.43）。
这项试点研究在医院环境中使用两种不同场景，对来自两个不同数据库的潜在天然健康产品与药物相互作用进行了比较。该研究揭示了NSD和NMCD中每种药物的天然健康产品与药物相互作用对的数量众多且各不相同。有必要进行进一步研究，以评估供应商和天然健康产品数据库提供的信息的相关性和层级。
