Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, 5501 Hopkins Bayview Circle/1A.2, Baltimore, MD 21224, USA.
Immunol Res. 2010 Jul;47(1-3):3-13. doi: 10.1007/s12026-009-8134-5.
Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.
蛋白酪氨酸磷酸酶 SHP-1 是许多不同信号通路中必不可少的调节分子。母系遗传性肥胖症（motheaten）突变鼠的免疫紊乱涉及多个器官，以及异常 SHP-1 表达与几种人类疾病的密切关联，这些都突显了 SHP-1 的生物学重要性。最近的研究提供了一些令人信服的证据，支持 SHP-1 在调节肥大细胞发育和功能以及调节先天和适应性免疫反应中的 2 型过敏炎症反应中的作用。本文总结了我们对这种在过敏炎症这一重要领域中有趣的磷酸酶的理解的最新进展。
