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1
Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation.酪氨酸磷酸酶 SHP-1 在过敏和过敏炎症中的作用。
Immunol Res. 2010 Jul;47(1-3):3-13. doi: 10.1007/s12026-009-8134-5.
2
SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis.SHP-1 调节变应性炎症和过敏反应中的肥大细胞功能。
PLoS One. 2013;8(2):e55763. doi: 10.1371/journal.pone.0055763. Epub 2013 Feb 4.
3
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.含Src同源2结构域的酪氨酸磷酸酶SHP-1控制过敏性气道炎症的发展。
J Clin Invest. 2003 Jan;111(1):109-19. doi: 10.1172/JCI15719.
4
SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung.缺乏 SHP-1 的肥大细胞对刺激反应过度，在肺部引发过敏炎症中起关键作用。
J Immunol. 2010 Feb 1;184(3):1180-90. doi: 10.4049/jimmunol.0901972. Epub 2009 Dec 30.
5
NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module.NecroX-5 通过调节 SHP-1-Syk 信号模块抑制 IgE/Ag 刺激的过敏反应和肥大细胞活化。
Allergy. 2016 Feb;71(2):198-209. doi: 10.1111/all.12786. Epub 2015 Nov 23.
6
Sauchinone suppresses FcεRI-mediated mast cell signaling and anaphylaxis through regulation of LKB1/AMPK axis and SHP-1-Syk signaling module.双氢青蒿素通过调节 LKB1/AMPK 轴和 SHP-1-Syk 信号模块抑制 FcεRI 介导的肥大细胞信号转导和过敏反应。
Int Immunopharmacol. 2019 Sep;74:105702. doi: 10.1016/j.intimp.2019.105702. Epub 2019 Jun 20.
7
Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway.全氟辛烷磺酸通过激活SHP-1信号通路减弱IgE/抗原刺激的肥大细胞活化及过敏反应。
Chemosphere. 2025 Mar;372:144119. doi: 10.1016/j.chemosphere.2025.144119. Epub 2025 Jan 18.
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Isobavachin attenuates FcεRI-mediated inflammatory allergic responses by regulating SHP-1-dependent Fyn/Lyn/Syk/Lck signaling.异补骨脂查耳酮通过调节依赖于SHP-1的Fyn/Lyn/Syk/Lck信号传导来减轻FcεRI介导的炎症性过敏反应。
Biochem Pharmacol. 2025 Feb;232:116698. doi: 10.1016/j.bcp.2024.116698. Epub 2024 Dec 4.
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Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.含Src同源区2结构域的磷酸酶1对高亲和力IgE受体信号传导的正负调控
J Immunol. 2008 Oct 15;181(8):5414-24. doi: 10.4049/jimmunol.181.8.5414.
10
DJ-1 regulates mast cell activation and IgE-mediated allergic responses.DJ-1 调控肥大细胞活化和 IgE 介导的过敏反应。
J Allergy Clin Immunol. 2013 Jun;131(6):1653-62. doi: 10.1016/j.jaci.2012.10.012. Epub 2012 Nov 22.
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Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN.沙利度胺通过上调 SHP-1 信号转导并干扰 CRBN 的作用来减轻肥大细胞活化。
Cells. 2023 Feb 1;12(3):469. doi: 10.3390/cells12030469.
2
Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease.变应性疾病背景下的 IL-4/IL-13 细胞因子信号转导的调节。
J Allergy Clin Immunol. 2022 Aug;150(2):266-276. doi: 10.1016/j.jaci.2022.06.012.
3
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy.靶向蛋白磷酸酶治疗炎症相关疾病：从信号转导到治疗。
Signal Transduct Target Ther. 2022 Jun 4;7(1):177. doi: 10.1038/s41392-022-01038-3.
4
SHP-1 suppresses the antiviral innate immune response by targeting TRAF3.SHP-1 通过靶向 TRAF3 抑制抗病毒先天免疫反应。
FASEB J. 2020 Sep;34(9):12392-12405. doi: 10.1096/fj.202000600RR. Epub 2020 Jul 23.
5
Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.髓系细胞中 Ets-2 的缺失可减轻由 Ptpn6 点突变引起的 IL-1α 介导体炎性疾病。
Cell Mol Immunol. 2021 Jul;18(7):1798-1808. doi: 10.1038/s41423-020-0398-7. Epub 2020 Mar 19.
6
Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia.肝细胞 SHP-1 是内毒素血症期间炎症的关键调节因子。
Sci Rep. 2017 May 22;7(1):2218. doi: 10.1038/s41598-017-02512-7.
7
Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation.Toll 样受体、髓样细胞表达的触发受体家族成员和晚期糖基化终产物受体在过敏性气道炎症中的作用。
Expert Rev Respir Med. 2016 Feb;10(2):171-84. doi: 10.1586/17476348.2016.1133303. Epub 2016 Jan 20.
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Alterations of cell cycle control proteins SHP‑1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells.放射抗性鼻咽癌细胞中细胞周期调控蛋白SHP-1/2、p16、CDK4和细胞周期蛋白D1的改变
Mol Med Rep. 2014 Oct;10(4):1709-16. doi: 10.3892/mmr.2014.2463. Epub 2014 Aug 7.
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SHP1-mediated cell cycle redistribution inhibits radiosensitivity of non-small cell lung cancer.SHP1 介导的细胞周期重分布抑制非小细胞肺癌的放射敏感性。
Radiat Oncol. 2013 Jul 10;8:178. doi: 10.1186/1748-717X-8-178.
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Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase.不同的伙伴，相反的结果：色氨酸 2,3-双加氧酶免疫生物学的新视角。
Mol Med. 2012 Jul 18;18(1):834-42. doi: 10.2119/molmed.2012.00029.
本文引用的文献
1
SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung.缺乏 SHP-1 的肥大细胞对刺激反应过度，在肺部引发过敏炎症中起关键作用。
J Immunol. 2010 Feb 1;184(3):1180-90. doi: 10.4049/jimmunol.0901972. Epub 2009 Dec 30.
2
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.多发性硬化症患者的巨噬细胞表现出SHP-1表达不足和炎症表型增强。
Lab Invest. 2009 Jul;89(7):742-59. doi: 10.1038/labinvest.2009.32. Epub 2009 Apr 27.
3
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.T细胞中的SHP-1和SHP-2：在多个层面发挥作用的两种磷酸酶
Immunol Rev. 2009 Mar;228(1):342-59. doi: 10.1111/j.1600-065X.2008.00760.x.
4
The tyrosine kinase network regulating mast cell activation.调节肥大细胞活化的酪氨酸激酶网络。
Immunol Rev. 2009 Mar;228(1):149-69. doi: 10.1111/j.1600-065X.2008.00742.x.
5
A critical role of SHP-1 in regulation of type 2 inflammation in the lung.SHP-1在肺部2型炎症调节中的关键作用。
Am J Respir Cell Mol Biol. 2009 May;40(5):568-74. doi: 10.1165/rcmb.2008-0225OC. Epub 2008 Oct 23.
6
Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.含Src同源区2结构域的磷酸酶1对高亲和力IgE受体信号传导的正负调控
J Immunol. 2008 Oct 15;181(8):5414-24. doi: 10.4049/jimmunol.181.8.5414.
7
Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation.氧化应激与过敏性气道炎症发展过程中的酪氨酸磷酸酶SHP-1
Am J Respir Cell Mol Biol. 2008 Oct;39(4):412-9. doi: 10.1165/rcmb.2007-0229OC. Epub 2008 Apr 25.
8
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.多发性硬化症患者外周血单核细胞中SHP-1缺乏与炎症基因表达增加
Lab Invest. 2008 Mar;88(3):243-55. doi: 10.1038/labinvest.3700720. Epub 2008 Jan 21.
9
A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases.一种通过激活FcγRIIB、含SH2结构域的肌醇磷酸酶1和含SH2结构域的蛋白酪氨酸磷酸酶来抑制肥大细胞的小鼠Fcγ-Fε蛋白。
J Allergy Clin Immunol. 2008 Feb;121(2):441-447.e5. doi: 10.1016/j.jaci.2007.08.051. Epub 2007 Oct 18.
10
Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.大鼠嗜碱性白血病-2H3细胞中含Src同源区2结构域的磷酸酶-1的负向自动调节
Int Immunol. 2007 Sep;19(9):1049-61. doi: 10.1093/intimm/dxm070. Epub 2007 Aug 3.
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