Department of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, CA 90840, USA.
Angew Chem Int Ed Engl. 2010 Feb 8;49(7):1267-70. doi: 10.1002/anie.200906248.
The chiral induction reagent (e.g., D-, L-camphoric acid) exhibits two distinct roles: (1) enable and catalyze growth of chiral crystals, and (2) control chirality of Mn(HCOO)(adc) crystals (H2adc = adamantane-1,3-dicarboxylic acid. Time-dependent experiments show the initial crystallization of an achiral phase Mn(adc), which persists in the absence of chiral induction agent, but is slowly converted into enantioenriched Mn(HCOO)(adc) in the presence of chiral induction agent such as D-camphoric acid, operating in synergy with generated formate.
手性诱导试剂(例如,D-、L-樟脑酸)具有两个截然不同的作用:(1)使手性晶体的生长成为可能并催化其生长,(2)控制 Mn(HCOO)(adc)晶体的手性(H2adc = 金刚烷-1,3-二羧酸)。时间依赖性实验表明,最初结晶出非手性相的 Mn(adc),在没有手性诱导剂的情况下,它会持续存在,但在存在手性诱导剂(如 D-樟脑酸)的情况下,它会缓慢地转化为富集对映体的 Mn(HCOO)(adc),与生成的甲酸盐协同作用。