Xiong Chang-Hui, Liang Xiao-Feng, Wang Hua-Qing
Nangchang City Center for Disease Control and Prevention, Nanchang 330006, Jiangxi, China.
Zhongguo Yi Miao He Mian Yi. 2009 Aug;15(4):358-62.
To Understand the protective efficacy of Bacillus Calmette Guerin (BCG) vacciation against children tuberculosis meningitis and millet tuberculosis, to provide the data to improve immune tactics of BCG.
A search CHKD full text database (1979-2007) and CHKD meeting paper database (1999-2008) and WANGFANG database (1982-2007), with BCG, tuberculosis meningitis, millet tuberculosis, then to analyze information from qualified literatures.
28 paper were involved. 25 were correlated with tuberculosis meningitis, 1 correlated with millet tuberculosis, 2 correlated with both. The study about protections of BCG against tuberculosis meningitis showed that BCG has protective action in ecology study. The inoculation of BCG in tuberculosis meningitis cases was 0-69.08%, millet tuberculosis BCG inoculating with 82.76%. Result of Mete analysis showed that it was 81% to the protection tuberculosis meningitis, 95% CI is 57%-91%.
BCG vaccine has protective effect for preventing tuberculous meningitis. Due to lack of case-control study, cases in vaccinated and unvaccinated ratio should not an objective description of the effect of BCG vaccination. Protective effect of miliary tuberculosis research literature was less, unable to come to precise conclusions.
了解卡介苗接种对儿童结核性脑膜炎和粟粒性结核的保护效果，为完善卡介苗免疫策略提供依据。
检索CHKD全文数据库（1979 - 2007年）、CHKD会议论文数据库（1999 - 2008年）及万方数据库（1982 - 2007年），以卡介苗、结核性脑膜炎、粟粒性结核为检索词，对纳入合格文献进行信息分析。
共纳入28篇文献。其中25篇与结核性脑膜炎相关，1篇与粟粒性结核相关，2篇两者均相关。卡介苗对结核性脑膜炎保护作用的研究表明，卡介苗在生态学研究中有保护作用。结核性脑膜炎病例卡介苗接种率为0 - 69.08%，粟粒性结核卡介苗接种率为82.76%。Meta分析结果显示，对结核性脑膜炎的保护率为81%，95%CI为57% - 91%。
卡介苗对预防结核性脑膜炎有保护作用。因缺乏病例对照研究，接种与未接种病例的比例不能客观描述卡介苗接种效果。粟粒性结核保护作用的研究文献较少，无法得出确切结论。
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