Markovits Noa, Ben Amotz Ami, Levy Yishai
Department of Medicine D, Rambam Health Care Campus, Haifa, Israel.
Isr Med Assoc J. 2009 Oct;11(10):598-601.
Fat tissue mediates the production of inflammatory cytokines and oxidative products, which are key steps in the development of type 2 diabetes and atherosclerosis. Antioxidant-rich diets protect against chronic diseases. Antioxidants may interfere with pro-inflammatory signals.
To investigate the effect of the potent tomato-derived antioxidant carotenoid, lycopene, on plasma antioxidants (carotenoids and vitamin E), inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-alpha) and oxidation products (conjugated dienes).
Eight obese patients (body mass index 37.5 +/- 2.5 kg/m2) were compared with a control group of eight lean, age and gender-matched subjects (BMI 21.6 +/- 0.6 kg/m2), before and after 4 weeks of lycopene supplementation (tomato-derived Lyc-O-Mato) (30 mg daily).
Plasma carotenoids were significantly reduced in the obese compared to control subjects (0.54 +/- 0.06 vs. 0.87 +/- 0.08 microg/ml, P < 0.01). CRP levels were significantly higher (6.5 vs. 1.1 mg/L, P = 0.04) in obese vs. controls, as were IL-6 and conjugated dienes (3.6 and 7.9-fold, respectively). CRP, IL-6 and conjugated dienes correlated with BMI, while IL-6 and conjugated dienes correlated inversely with carotenoids (P < 0.05). Following lycopene treatment, a significant elevation of plasma carotenoids (1.79 vs. 0.54 microg/ml) and specifically lycopene (1.15 vs 0.23 microg/ml) (P < 0.001) occurred in the treatment vs. the placebo group, respectively. Markers of inflammation and oxidation products were not altered by lycopene.
Obese patients showed abnormally higher markers of inflammation and oxidation products and lower plasma carotenoids. The lack of reduction of pro-inflammatory markers could be attributed to the short period of the study and the small number of participants. More studies are needed on the protective qualities of natural antioxidant-rich diets against obesity-related co-morbidities.
脂肪组织介导炎症细胞因子和氧化产物的产生，这是2型糖尿病和动脉粥样硬化发展的关键步骤。富含抗氧化剂的饮食可预防慢性疾病。抗氧化剂可能会干扰促炎信号。
研究强效的番茄源抗氧化类胡萝卜素——番茄红素，对血浆抗氧化剂（类胡萝卜素和维生素E）、炎症标志物（C反应蛋白、白细胞介素-6、肿瘤坏死因子-α）和氧化产物（共轭二烯）的影响。
将8名肥胖患者（体重指数37.5±2.5kg/m²）与8名年龄、性别匹配的瘦人对照组（BMI 21.6±0.6kg/m²）进行比较，在补充番茄红素（番茄源Lyc-O-Mato）（每日30mg）4周前后进行比较。
与对照组相比，肥胖患者血浆类胡萝卜素显著降低（0.54±0.06 vs. 0.87±0.08μg/ml，P<0.01）。肥胖患者的CRP水平显著高于对照组（6.5 vs. 1.1mg/L，P = 0.04），IL-6和共轭二烯也是如此（分别为3.6倍和7.9倍）。CRP、IL-6和共轭二烯与BMI相关，而IL-6和共轭二烯与类胡萝卜素呈负相关（P<0.05）。番茄红素治疗后，治疗组与安慰剂组相比，血浆类胡萝卜素显著升高（1.79 vs. 0.54μg/ml），特别是番茄红素（1.15 vs 0.23μg/ml）（P<0.001）。番茄红素未改变炎症标志物和氧化产物。
肥胖患者表现出炎症和氧化产物标志物异常升高，血浆类胡萝卜素降低。促炎标志物缺乏降低可能归因于研究时间短和参与者数量少。需要更多关于富含天然抗氧化剂的饮食对肥胖相关合并症保护作用的研究。
