Visioli Francesco, Riso Patrizia, Grande Simona, Galli Claudio, Porrini Marisa
Department of Pharmacological Science, University of Milan, Via Balzaretti 9, 20133, Milano, Italy,
Eur J Nutr. 2003 Aug;42(4):201-6. doi: 10.1007/s00394-003-0415-5.
It has been suggested that regular consumption of tomato products improves antioxidant defenses due to their endogenous antioxidant compounds, notably lycopene.
We evaluated the effects of tomato consumption on parameters of lipid oxidation in healthy human volunteers.
Twelve females (enrolled at T-7), after a one-week of carotenoid-poor diet (T0), were instructed to supplement the same diet with different tomato products (raw, sauce, and paste), thereby providing approximately eight mg lycopene/day for three weeks (T21). Blood samples were periodically collected in order to evaluate plasma carotenoid concentrations, plasma antioxidant capacity, and susceptibility of LDL to metal ion-induced oxidation. Furthermore, 8-iso-PGF(2alpha), a marker of in vivo oxidative stress, was analyzed in the 24-hour urine.
Carotenoid concentrations decreased significantly during the carotenoid-poor diet (P < 0.05), while lycopene concentrations increased significantly after tomato consumption (P < 0.001). The antioxidant capacity of plasma did not vary during the study. Conversely, LDL oxidizability decreased after tomato consumption, as demonstrated by a shortening of the lag phase (P < 0.001). This parameter was significantly correlated with lycopene concentration (r = 0.36, P < 0.05). The excretion of 8-iso-PGF(2alpha) in urine was also significantly lower (-53%, P < 0.05 compared with T0) after tomato supplementation.
These results further support a role for tomato products in the prevention of lipid peroxidation, a risk factor of atherosclerosis and cardiovascular disease.
有人提出，经常食用番茄制品可因其内源性抗氧化化合物（尤其是番茄红素）而改善抗氧化防御能力。
我们评估了食用番茄对健康人类志愿者脂质氧化参数的影响。
12名女性（在T - 7时入组），在经过一周的低类胡萝卜素饮食（T0）后，被要求在相同饮食中补充不同的番茄制品（生番茄、番茄酱和番茄糊），连续三周每天提供约8毫克番茄红素（T21）。定期采集血样以评估血浆类胡萝卜素浓度、血浆抗氧化能力以及低密度脂蛋白对金属离子诱导氧化的敏感性。此外，还分析了24小时尿液中的体内氧化应激标志物8 - 异前列腺素F2α（8-iso-PGF(2α)）。
在低类胡萝卜素饮食期间，类胡萝卜素浓度显著下降（P < 0.05），而食用番茄后番茄红素浓度显著增加（P < 0.001）。在研究期间，血浆的抗氧化能力没有变化。相反，食用番茄后低密度脂蛋白的氧化能力下降，表现为滞后期缩短（P < 0.001）。该参数与番茄红素浓度显著相关（r = 0.36，P < 0.05）。补充番茄后，尿液中8 - 异前列腺素F2α（8-iso-PGF(2α)）的排泄量也显著降低（与T0相比降低了53%，P < 0.05）。
这些结果进一步支持了番茄制品在预防脂质过氧化方面的作用，脂质过氧化是动脉粥样硬化和心血管疾病的一个危险因素。
