Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Paediatr Perinat Epidemiol. 2010 Jan;24(1):31-4. doi: 10.1111/j.1365-3016.2009.01089.x.
Vaginal bleeding during pregnancy has been considered a marker of an at-risk pregnancy, but the accuracy of reported bleeding has not been assessed. We sought to evaluate the agreement in vaginal bleeding reports based on prospective daily diary and retrospective recall at first-trimester interview and to investigate predictors of reporting accuracy. Participants recruited prior to pregnancy for a community-based pregnancy cohort (n = 153) completed web-based daily diaries beginning before pregnancy until the end of the first trimester. A comprehensive first-trimester interview was conducted, and the bleeding data from diary and interview were compared. Kappa statistics were used to quantify agreement. Log-linear models were used to investigate maternal age, prior miscarriage, and current pregnancy outcome as potential predictors of agreement. We found that bleeding characteristics (number of bleeding episodes, bleeding heaviness, duration and gestational timing) from the diary and interview were reported with high levels of agreement. Kappas ranged from 0.77 to 0.84. Retrospective report of any bleeding had a sensitivity of 0.80 and specificity of 1.0; however, sensitivity was lower when examined within smaller time intervals. Important predictors of agreement were not identified in this analysis, but the sample was small. Overall, the presence of vaginal bleeding, a common and potentially alarming symptom of early pregnancy, may be assessed by interview later in pregnancy with reasonable accuracy.
孕期阴道出血一直被认为是高危妊娠的一个标志,但报告出血的准确性尚未得到评估。我们旨在评估基于前瞻性每日日记和首次妊娠面谈时的回顾性回忆的阴道出血报告的一致性,并探讨报告准确性的预测因素。在社区为基础的妊娠队列中(n=153),参与者在妊娠前招募并完成了基于网络的每日日记,从妊娠前开始记录,直到第一孕期结束。进行了全面的第一孕期面谈,并比较了日记和面谈中的出血数据。Kappa 统计用于量化一致性。对数线性模型用于研究产妇年龄、既往流产和当前妊娠结局作为一致性的潜在预测因素。我们发现,日记和面谈中报告的出血特征(出血次数、出血严重程度、持续时间和妊娠时间)具有高度一致性。Kappa 值范围为 0.77 至 0.84。任何出血的回顾性报告的敏感性为 0.80,特异性为 1.0;然而,当在较小的时间间隔内检查时,敏感性较低。在这项分析中没有确定一致性的重要预测因素,但样本较小。总体而言,孕期阴道出血的存在,这是一种常见且可能令人警惕的早期妊娠症状,可能可以在妊娠后期通过面谈进行合理的准确评估。