Sun Lu, Tao Fangbiao, Hao Jiahu, Su Puyu, Liu Fang, Xu Rong
Department of Maternal, Child & Adolescent Health, School of Public Health, Hefei, China.
J Matern Fetal Neonatal Med. 2012 Aug;25(8):1297-301. doi: 10.3109/14767058.2011.632034. Epub 2011 Nov 22.
To examine the effect of first trimester vaginal bleeding on adverse pregnancy outcomes including preterm delivery, low birth weight and small for gestational age.
This is a prospective population-based cohort study. A questionnaire survey was conducted on 4342 singleton pregnancies by trained doctors. Binary logistic regression was used to estimate risk ratios (RRs) and 95% confidence intervals (95% CI).
Vaginal bleeding occurred among 1050 pregnant women, the incidence of vaginal bleeding was 24.2%, 37.4% of whom didn't see a doctor, 62.6% of whom saw a doctor for vaginal bleeding. Binary logistic regression demonstrated that bleeding with seeing a doctor was significantly associated with preterm birth (RR 1.84, 95% CI 1.25-2.69) and bleeding without seeing a doctor was related to increased of low birth weight (RR 2.52, 95% CI 1.34-4.75) and was 1.97-fold increased of small for gestational age (RR 1.97, 95% CI 1.19-3.25).
These results suggest that first trimester vaginal bleeding is an increased risk of low birth weight, preterm delivery and small for gestational age. Find ways to reduce the risk of vaginal bleeding and lower vaginal bleeding rate may be helpful to reduce the incidence of preterm birth, low birth weight and small for gestational age.
探讨孕早期阴道出血对不良妊娠结局的影响，包括早产、低出生体重和小于胎龄儿。
这是一项基于人群的前瞻性队列研究。由经过培训的医生对4342例单胎妊娠进行问卷调查。采用二元逻辑回归估计风险比（RRs）和95%置信区间（95%CI）。
1050例孕妇发生阴道出血，阴道出血发生率为24.2%，其中37.4%未就医，62.6%因阴道出血就医。二元逻辑回归显示，就医时出血与早产显著相关（RR 1.84，95%CI 1.25 - 2.69），未就医出血与低出生体重增加相关（RR 2.52，95%CI 1.34 - 4.75），小于胎龄儿增加1.97倍（RR 1.97，95%CI 1.19 - 3.25）。
这些结果表明，孕早期阴道出血会增加低出生体重、早产和小于胎龄儿的风险。寻找降低阴道出血风险的方法并降低阴道出血率可能有助于降低早产、低出生体重和小于胎龄儿的发生率。
