Brady Tammy M, Parekh Rulan S
Pediatr Transplant. 2010 Feb;14(1):6-9. doi: 10.1111/j.1399-3046.2009.01288.x.
Children with kidney disease are at increased risk of having several comorbidities such as obesity, dyslipidemia, hypertension, and impaired glucose tolerance, and patients with a constellation of these symptoms are considered to have the MS. Children with kidney disease, and ESRD in particular, are at increased CV risk, as are patients with the MS. To determine the impact MS has on a particularly vulnerable population of children, those who have received a kidney transplant, Wilson et al. explored the prevalence of MS and the association of MS with cardiac abnormalities among this subset of children. They found an overall high prevalence of MS among pediatric transplant recipients and that the risk of left ventricular hypertrophy was higher among children with MS after renal transplant compared to those without MS. Review of the most common definitions of MS and also the clinical implications are discussed. While there is no doubt that children with kidney disease have a high prevalence of CV risk factors and that these children are at risk for CV events early in life, whether the sum of the parts of MS confers increased risk over what is seen with individual risk factors that often run together remains to be seen.
患有肾脏疾病的儿童出现多种合并症的风险增加，如肥胖、血脂异常、高血压和糖耐量受损，出现这些症状群的患者被认为患有代谢综合征（MS）。患有肾脏疾病的儿童，尤其是终末期肾病（ESRD）患者，心血管疾病（CV）风险增加，MS患者也是如此。为了确定MS对一个特别脆弱的儿童群体（即接受肾移植的儿童）的影响，威尔逊等人探讨了该儿童亚组中MS的患病率以及MS与心脏异常的关联。他们发现儿科移植受者中MS的总体患病率较高，并且肾移植后患有MS的儿童左心室肥厚的风险高于未患MS的儿童。文中讨论了MS最常见定义及其临床意义。虽然毫无疑问，患有肾脏疾病的儿童心血管危险因素的患病率很高，并且这些儿童在生命早期就有发生心血管事件的风险，但MS各部分因素综合起来是否会比通常同时出现的个体危险因素带来更高的风险，仍有待观察。
