McLin Valérie A, Belli Dominique C, Posfay-Barbe Klara M
Department of Pediatrics, Children's Hospital of Geneva, University Hospitals of Geneva, Geneva, Switzerland.
Pediatr Transplant. 2010 Feb;14(1):19-22. doi: 10.1111/j.1399-3046.2009.01265.x.
The IRIS was initially described in HIV-positive patients as a sudden clinical deterioration after the introduction of highly active retroviral therapy. It is believed that IRIS is caused by a restored and exaggerated inflammatory immune response to different infectious or non-infectious triggers. This abnormal response is the consequence of an imbalance between pro-inflammatory and anti-inflammatory states. Recently, IRIS has also been reported in adult SOT recipients, causing local and systemic manifestations, and compromising long-term graft function and patient survival. However, IRIS has to date not been reported in pediatric SOT recipients. Here we review what is known and speculated about the pathogenesis of IRIS and propose that children may be relatively protected from IRIS.
免疫重建炎症综合征（IRIS）最初在HIV阳性患者中被描述为在引入高效抗逆转录病毒治疗后突然出现的临床病情恶化。据信，IRIS是由对不同感染性或非感染性触发因素恢复并过度的炎症免疫反应引起的。这种异常反应是促炎状态和抗炎状态失衡的结果。最近，成人实体器官移植受者中也报告了IRIS，导致局部和全身表现，并损害长期移植物功能和患者生存。然而，迄今为止，儿科实体器官移植受者中尚未报告过IRIS。在此，我们回顾了关于IRIS发病机制的已知和推测内容，并提出儿童可能相对不易发生IRIS。
