古柯糊：化学分析与吸食实验
Coca paste: chemical analysis and smoking experiments.
作者信息
elSohly M A, Brenneisen R, Jones A B
机构信息
Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi.
出版信息
J Forensic Sci. 1991 Jan;36(1):93-103.
Several samples of Colombian and a sample of Peruvian coca paste were subjected to chemical analysis to ascertain the complexity of these products. A neutral and acid fraction and a basic fraction were analyzed by gas chromatography/flame ionization detection (GC/FID) and gas chromatography/mass spectrometry (GC/MS). The basic fraction was also analyzed as its trimethylsilyl (TMS) derivative. Several gasoline residue components were identified in the neutral fraction. In addition to cocaine (greater than 60% in all cases), other alkaloids were identified. Lead and manganese analyses were carried out on these samples. While all the samples contained no lead (less than 45 ppm), most of the Colombian samples contained significant amounts of manganese (greater than 5%). Preliminary smoking experiments with a Colombian coca paste sample indicated that it behaves more like free cocaine than like a cocaine sulfate salt.
对几份哥伦比亚古柯糊样本和一份秘鲁古柯糊样本进行了化学分析，以确定这些产品的成分复杂性。通过气相色谱/火焰离子化检测（GC/FID）和气相色谱/质谱联用（GC/MS）对一个中性和酸性馏分以及一个碱性馏分进行了分析。碱性馏分还作为其三甲基硅烷基（TMS）衍生物进行了分析。在中性馏分中鉴定出了几种汽油残留成分。除了可卡因（在所有情况下均大于60%）外，还鉴定出了其他生物碱。对这些样本进行了铅和锰分析。虽然所有样本均不含铅（低于45 ppm），但大多数哥伦比亚样本含有大量的锰（大于5%）。用一份哥伦比亚古柯糊样本进行的初步吸食实验表明，它的行为更像游离可卡因，而不像硫酸可卡因盐。
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