古柯叶和非法可卡因样本中假可卡因的检测与测定。
Detection and determination of pseudococaine in coca leaves and illicit cocaine samples.
作者信息
Casale J F, Moore J M
机构信息
U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, VA.
出版信息
J Forensic Sci. 1994 Nov;39(6):1537-43.
Methodology is presented for the isolation, identification and determination of pseudococaine in coca leaves and illicit cocaine. Coca leaves, crude cocaine base (coca paste), refined cocaine base and refined cocaine hydrochloride, all derived from the same geographic location in Bolivia, were examined. Pseudococaine and other coca alkaloids were isolated from leaf samples using toluene extraction followed by acid/Celite trap and ion-pair column chromatography, and from crude and refined cocaine samples by acid/Celite column ion-pairing chromatography. Mass spectral analysis of coca leaf isolates confirmed the presence of pseudococaine. Pseudococaine was quantified by capillary gas chromatography with flame ionization detection at levels of 0.0001-0.035% (relative to cocaine) in refined illicit cocaine and coca leaves.
介绍了从古柯叶和非法可卡因中分离、鉴定和测定假可卡因的方法。对所有源自玻利维亚同一地理位置的古柯叶、粗制可卡因碱（古柯糊）、精制可卡因碱和精制盐酸可卡因进行了检测。使用甲苯萃取，然后通过酸/硅藻土捕集和离子对柱色谱法从古柯叶样品中分离出假可卡因和其他古柯生物碱，通过酸/硅藻土柱离子对色谱法从粗制和精制可卡因样品中分离出假可卡因和其他古柯生物碱。对古柯叶分离物进行质谱分析证实了假可卡因的存在。采用带火焰离子化检测的毛细管气相色谱法对精制非法可卡因和古柯叶中含量为0.0001 - 0.035%（相对于可卡因）的假可卡因进行定量。
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