[维生素D受体基因多态性与结核病易感性关系的Meta分析]

[Meta-analysis of relationship of vitamin D receptor gene polymorphism and tuberculosis susceptibility].

作者信息

Zhao Zhen-zhen, Zhang Tian-zhe, Gao Yong-ming, Feng Fu-min

机构信息

Department of Epidemiology and Statistics North China Coal Medical University, Tangshan, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2009 Oct;32(10):748-51.

PMID:20079241

Abstract

OBJECTIVE

To provide a quantitative summary in estimating the association between polymorphisms of 2 loci of FokI and TaqI in vitamin D receptor gene and susceptibility to tuberculosis by means of meta-analysis.

METHODS

Databases CNKI, CBM, WanFang DATA, MEDLINE and PubMed were searched using "VDR", "polymorphisms" or "alleles", in combination with "tuberculosis", and a manual search of citations from relevant original studies and literature was also performed between January 1980 and November 2007. RevMan 4.2 was applied in the process of analyzing the data of 14 case-control studies.

RESULTS

The summary ORs for studies with polymorphisms of FokI, TaqI loci of the VDR gene were 1.12 (95%CI: 0.98 - 1.28) in Ff vs FF, 1.66 (95%CI: 1.12 - 2.46) in ff vs FF, 0.97 (95%CI: 0.82 - 1.14) in Tt vs TT, 1.27 (95%CI: 0.96 - 1.69) in tt vs TT. The fail-safe number was 109.69 for FokI and 75.24 for TaqI. The analysis result was reliable.

CONCLUSION

Polymorphisms at FokI loci (VDR-ff) showed statistically significant association between the VDR variants and susceptibility to tuberculosis, and variant in the TaqI locus failed to show statistically significant association.

摘要

目的

通过荟萃分析定量总结维生素D受体基因FokI和TaqI两个位点的多态性与结核病易感性之间的关联。

方法

利用“VDR”“多态性”或“等位基因”与“结核病”相结合的方式检索中国知网、中国生物医学文献数据库、万方数据、MEDLINE和PubMed数据库，并在1980年1月至2007年11月期间对相关原始研究和文献的参考文献进行手工检索。采用RevMan 4.2软件对14项病例对照研究的数据进行分析。

结果

VDR基因FokI、TaqI位点多态性研究中，Ff与FF比较的汇总OR为1.12（95%CI：0.98 - 1.28），ff与FF比较为1.66（95%CI：1.12 - 2.46），Tt与TT比较为0.97（95%CI：0.82 - 1.14），tt与TT比较为1.27（95%CI：0.96 - 1.69）。FokI的失效安全数为109.69，TaqI的失效安全数为75.24。分析结果可靠。