[乳腺丝氨酸蛋白酶抑制剂在口腔鳞状细胞癌中的表达及其临床意义]
[Expression of mammary serine proteinase inhibitor in oral squamous cell carcinoma and its clinical significance].
作者信息
Luo Jun, Zhou Lan, Zheng Gen-jian, Ji Tong, Zhong Lai-ping
机构信息
Department of Oral and Maxillofacial Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Oct;44(10):606-10.
OBJECTIVE
To investigate the expression of mammary serine proteinase inhibitor(Maspin) in patients with oral squamous cell carcinoma and its relationship with clinicopathological features.
METHODS
The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in non-malignant oral epithelia by immunohistochemical staining. The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed.
RESULTS
The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia (P = 0.001). Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis (P = 0.038). Positive Maspin protein expression indicated negative lymph node metastasis, and negative correlation was also found between the Maspin protein expression and the postoperative metastasis (P = 0.004). Positive correlation was found between the Maspin expression and the patients' survival rate (P = 0.014), patients with positive Maspin protein expression having higher survival rate than those with negative Maspin expression.
CONCLUSIONS
Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.
目的
探讨乳腺丝氨酸蛋白酶抑制剂（Maspin）在口腔鳞状细胞癌患者中的表达及其与临床病理特征的关系。
方法
采用免疫组织化学染色法检测45例口腔鳞状细胞癌患者及非恶性口腔上皮组织中Maspin蛋白的表达情况，并对Maspin蛋白表达与临床病理参数之间的关系进行统计学分析。
结果
口腔鳞状细胞癌癌组织中Maspin蛋白表达低于非恶性口腔上皮组织（P = 0.001）。癌组织中Maspin蛋白表达与淋巴结转移状况呈负相关（P = 0.038）。Maspin蛋白表达阳性提示无淋巴结转移，且Maspin蛋白表达与术后转移也呈负相关（P = 0.004）。Maspin表达与患者生存率呈正相关（P = 0.014），Maspin蛋白表达阳性的患者生存率高于Maspin表达阴性的患者。
结论
Maspin可能作为口腔鳞状细胞癌潜在的预后标志物。
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