Yu Xiao-Yun, Tu Lei, Yang Jie, Hou Xiao-Hua, Qian Wei, Chen Jian-de
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Email:
Zhonghua Nei Ke Za Zhi. 2009 Nov;48(11):951-4.
The aims of this study were to investigate the effects of cisplatin (DDP) on gastric myoelectrical activity and the roles of gastric electrical stimulation (GES) in the treatment of drug-induced emesis in dogs.
Four pairs of electrodes were implanted in gastric serosa in seven female dogs, all dogs performed followed two-session study: intravenous infusion of DDP (1.5 mg/kg) was given for 1 h in DDP-control session and DDP-GES session. Trains of short pulses GES was applied on the proximal pair of gastric electrodes from drugs infusion. It lasted 6 h in GES session. Gastric slow waves and animal behaviors were recorded in each session.
(1) DDP induced nausea and gastric dysrhythmia. The total number of emesis was 5.5 +/- 1.2 in DDP-control session, and the total symptom score was 31.83 +/- 2.75. The gastric slow wave showed both bradygastria and tachygastria during the period of emesis (P = 0.031 and 0.020 vs baseline). The percentage of normal slow wave was (69.61 +/- 5.81)% during this period (P = 0.003 vs baseline). (2) GES reduced emesis and the animal behavioral score suggestive of nausea compared with DDP-control sessions. The total behavioral score and total number of emesis decreased in this session (all the P < 0.05). However, GES had no effects on gastric dysrhythmia.
DDP induced emesis and gastric dysrhythmia. GES with trains of short pulses relieves drug-induced emetic responses but has no effects on dysrhythmia.
本研究旨在探讨顺铂（DDP）对犬胃肌电活动的影响以及胃电刺激（GES）在治疗犬药物性呕吐中的作用。
在7只雌性犬的胃浆膜植入4对电极，所有犬进行两个阶段的研究：在DDP-对照阶段和DDP-GES阶段静脉输注DDP（1.5mg/kg）1小时。从药物输注开始，在近端胃电极上施加短脉冲串GES。在GES阶段持续6小时。在每个阶段记录胃慢波和动物行为。
（1）DDP诱发恶心和胃节律紊乱。DDP-对照阶段呕吐总数为5.5±1.2，总症状评分为31.83±2.75。呕吐期间胃慢波显示出胃动过缓和胃动过速（与基线相比，P = 0.031和0.020）。在此期间正常慢波的百分比为（69.61±5.81）%（与基线相比，P = 0.003）。（2）与DDP-对照阶段相比，GES减少了呕吐和提示恶心的动物行为评分。该阶段总行为评分和呕吐总数均下降（所有P < 0.05）。然而，GES对胃节律紊乱无影响。
DDP诱发呕吐和胃节律紊乱。短脉冲串GES可减轻药物性呕吐反应，但对节律紊乱无影响。
