University of Minnesota, Department of Genetics, Cell Biology, and Development, Minneapolis, MN 55455, USA.
FEBS Lett. 2010 Apr 2;584(7):1342-9. doi: 10.1016/j.febslet.2010.01.006. Epub 2010 Jan 13.
Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes.
果蝇已被证明是研究自噬的有力模型，其调控涉及一个由 Atg 蛋白组成的核心机制，以及类似于酵母和哺乳动物的上游信号调节剂。自噬在降解蛋白质和细胞器方面的保守作用使其在协调多个细胞过程以及许多病理条件中具有重要功能。本文总结了果蝇自噬研究的关键研究，并讨论了可能导致更好地理解自噬在高等真核生物中的作用和调控的潜在问题。
