Emerging Evidence on Immunity: A Focus on Gene Expression Involved in Microbial Infection for Host-Pathogen Interaction Studies.

In recent years, the scientific community's interest in as an insect model to investigate immunity and host-pathogen interactions has considerably increased. The reasons for this growing interest could be explained by the peculiar features of this beetle, which offers various advantages compared to other invertebrates models commonly used in laboratory studies. Thus, this review aimed at providing a broad view of the immune system in light of the new scientific evidence on the developmental/tissue-specific gene expression studies related to microbial infection. In addition to the well-known cellular component and humoral response process, several studies investigating the factors associated with immune response or deepening of those already known have been reported. However, various aspects remain still less understood, namely the possible crosstalk between the immune deficiency protein and Toll pathways and the role exerted by apolipoprotein III in the expression of the antimicrobial peptides. Therefore, further research is required for to be recommended as an alternative insect model for pathogen-host interaction and immunity studies.