纤维蛋白原水平升高可预测 1 型糖尿病患者冠状动脉钙化进展。
Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.
机构信息
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA.
出版信息
Atherosclerosis. 2010 Jun;210(2):671-3. doi: 10.1016/j.atherosclerosis.2009.12.034. Epub 2010 Jan 4.
Abstract
AIM
To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.
METHODS
Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.
RESULTS
Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.
CONCLUSIONS
Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.
摘要
目的
确定纤维蛋白原水平是否可独立预测 1 型糖尿病患者冠状动脉钙化（CAC）的进展。
方法
对前瞻性队列研究——1 型糖尿病的冠状动脉钙化研究的数据进行评估。将基线时的纤维蛋白原水平分为四等份。在基线和 2.4±0.4 年后的随访时分别测量两次 CAC，并取平均值。CAC 进展者定义为在随访期间其 CAC 体积的平方根增加≥2.5mm3 或出现临床冠心病的患者。
结果
与非进展者相比，进展者的纤维蛋白原水平更高（276±61mg/dl 比 259±61mg/dl，p=0.0003）。在调整了已知心血管危险因素后，最高四分位数的 CAC 进展增加。
结论
较高的纤维蛋白原水平可预测 1 型糖尿病患者的 CAC 进展，独立于标准心血管危险因素。
相似文献
1
Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.纤维蛋白原水平升高可预测 1 型糖尿病患者冠状动脉钙化进展。
Atherosclerosis. 2010 Jun;210(2):671-3. doi: 10.1016/j.atherosclerosis.2009.12.034. Epub 2010 Jan 4.
2
Soluble interleukin-2 receptor as a marker for progression of coronary artery calcification in type 1 diabetes.可溶性白细胞介素-2受体作为1型糖尿病患者冠状动脉钙化进展的标志物
Int J Biochem Cell Biol. 2006;38(5-6):996-1003. doi: 10.1016/j.biocel.2005.09.015. Epub 2005 Oct 18.
3
Reduced heart rate variability predicts progression of coronary artery calcification in adults with type 1 diabetes and controls without diabetes.心率变异性降低可预测 1 型糖尿病成人及无糖尿病对照者冠状动脉钙化进展。
Diabetes Technol Ther. 2010 Dec;12(12):963-9. doi: 10.1089/dia.2010.0070.
4
Determinants of progression of coronary artery calcification in type 2 diabetes role of glycemic control and inflammatory/vascular calcification markers.2型糖尿病患者冠状动脉钙化进展的决定因素：血糖控制及炎症/血管钙化标志物的作用
J Am Coll Cardiol. 2007 Dec 4;50(23):2218-25. doi: 10.1016/j.jacc.2007.08.032. Epub 2007 Nov 19.
5
Serum Gamma-glutamyltransferase Levels Predict the Progression of Coronary Artery Calcification in Adults With Type 2 Diabetes Mellitus.血清γ-谷氨酰转移酶水平可预测2型糖尿病成人患者冠状动脉钙化的进展
Angiology. 2015 Aug;66(7):667-74. doi: 10.1177/0003319714548566. Epub 2014 Aug 26.
6
Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes.无糖尿病成年人的糖化血红蛋白与冠状动脉钙化进展
Diabetes Care. 2015 Jan;38(1):66-71. doi: 10.2337/dc14-0360. Epub 2014 Oct 16.
7
Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study.血清尿调蛋白可预测 1 型糖尿病成人在 12 年内冠状动脉钙化和糖尿病肾脏疾病的发生率较低：CACTI 研究。
Diabetes Care. 2019 Feb;42(2):297-302. doi: 10.2337/dc18-1527. Epub 2018 Nov 27.
8
Obesity and coronary artery calcium in diabetes: the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study.糖尿病与冠状动脉钙：1 型糖尿病冠状动脉钙化研究（CACTI）。
Diabetes Technol Ther. 2011 Oct;13(10):991-6. doi: 10.1089/dia.2011.0046. Epub 2011 Jul 19.
9
Serum S100A12 and Progression of Coronary Artery Calcification Over 4 Years in Hemodialysis Patients.血液透析患者血清S100A12与4年冠状动脉钙化进展情况
Am J Nephrol. 2015;42(1):4-13. doi: 10.1159/000438869. Epub 2015 Aug 13.
10
Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control.1型糖尿病患者冠状动脉钙化的进展：血糖控制的重要性。
Diabetes Care. 2003 Oct;26(10):2923-8. doi: 10.2337/diacare.26.10.2923.
引用本文的文献
1
Bridging Prevention and Imaging: The Influence of Statins on CAC and CCTA Findings.连接预防与成像：他汀类药物对冠状动脉钙化（CAC）和冠状动脉CT血管造影（CCTA）结果的影响
Curr Atheroscler Rep. 2025 Apr 8;27(1):50. doi: 10.1007/s11883-025-01287-x.
2
Preoperative laboratory parameters associated with deep vein thrombosis in patients with ovarian cancer: retrospective analysis of 3,147 patients in a single institute.术前实验室参数与卵巢癌患者深静脉血栓形成的关系：单一机构 3147 例患者的回顾性分析。
J Gynecol Oncol. 2024 Jul;35(4):e38. doi: 10.3802/jgo.2024.35.e38. Epub 2023 Dec 29.
3
Hemostatic state of children with type 1 diabetes.1型糖尿病患儿的止血状态
Ann Pediatr Endocrinol Metab. 2021 Jun;26(2):99-104. doi: 10.6065/apem.2040142.071. Epub 2021 Jun 30.
4
Non-traditional risk factors for coronary calcification and its progression in patients with type 2 diabetes: The impact of postprandial glycemia and fetuin-A.2型糖尿病患者冠状动脉钙化及其进展的非传统危险因素：餐后血糖和胎球蛋白-A的影响。
J Int Med Res. 2019 Feb;47(2):846-858. doi: 10.1177/0300060518814080. Epub 2019 Jan 7.
5
Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts.在ClinSeq®和弗雷明汉心脏研究队列中，基于基因型驱动识别预测晚期冠状动脉钙化的分子网络。
BMC Syst Biol. 2017 Oct 26;11(1):99. doi: 10.1186/s12918-017-0474-5.
6
Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis.动脉粥样硬化多族裔研究中冠状动脉钙化长期进展的危险因素。
J Am Heart Assoc. 2015 Aug 6;4(8):e001726. doi: 10.1161/JAHA.114.001726.
7
Clinical utility of the ratio between circulating fibrinogen and fibrin (ogen) degradation products for evaluating coronary artery disease in type 2 diabetic patients.循环纤维蛋白原与纤维蛋白（原）降解产物比值在评估2型糖尿病患者冠状动脉疾病中的临床应用
Chin Med J (Engl). 2015 Mar 20;128(6):727-32. doi: 10.4103/0366-6999.152465.
8
Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.纤维蛋白原与 2 型糖尿病合并稳定型冠状动脉疾病严重程度的相关性。
Dis Markers. 2014;2014:485687. doi: 10.1155/2014/485687. Epub 2014 Apr 6.
9
Effects of chitin and sepia ink hybrid hemostatic sponge on the blood parameters of mice.几丁质与乌贼墨复合止血海绵对小鼠血液参数的影响
Mar Drugs. 2014 Apr 10;12(4):2269-81. doi: 10.3390/md12042269.
10
Is the risk and nature of CVD the same in type 1 and type 2 diabetes?1 型和 2 型糖尿病的 CVD 风险和性质是否相同？
Curr Diab Rep. 2013 Jun;13(3):350-61. doi: 10.1007/s11892-013-0380-1.
本文引用的文献
1
Associations of inflammatory markers with coronary artery calcification: results from the Multi-Ethnic Study of Atherosclerosis.炎症标志物与冠状动脉钙化的相关性：来自动脉粥样硬化多民族研究的结果。
Atherosclerosis. 2010 Mar;209(1):226-9. doi: 10.1016/j.atherosclerosis.2009.08.037. Epub 2009 Aug 28.
2
Elevated fibrinogen levels and subsequent subclinical atherosclerosis: the CARDIA Study.纤维蛋白原水平升高与亚临床动脉粥样硬化：CARDIA研究
Atherosclerosis. 2009 Feb;202(2):623-31. doi: 10.1016/j.atherosclerosis.2008.05.039. Epub 2008 Jul 3.
3
Relationship between plasma sialic acid and fibrinogen concentration and incident micro- and macrovascular complications in type 1 diabetes. The EURODIAB Prospective Complications Study (PCS).1型糖尿病患者血浆唾液酸与纤维蛋白原浓度及微血管和大血管并发症发生风险的关系。欧洲糖尿病前瞻性并发症研究（PCS）。
Diabetologia. 2008 Mar;51(3):493-501. doi: 10.1007/s00125-007-0905-8. Epub 2008 Jan 9.
4
Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes.血清胱抑素C可预测1型糖尿病患者亚临床冠状动脉粥样硬化的进展。
Diabetes. 2007 Nov;56(11):2774-9. doi: 10.2337/db07-0539. Epub 2007 Jul 27.
5
Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability.评估冠状动脉钙化的变化：一种考虑扫描间变异性的分析方法。
AJR Am J Roentgenol. 2004 May;182(5):1327-32. doi: 10.2214/ajr.182.5.1821327.
6
Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.1型糖尿病对冠状动脉钙化性别差异的影响：胰岛素抵抗起作用吗？1型糖尿病冠状动脉钙化（CACTI）研究
Diabetes. 2003 Nov;52(11):2833-9. doi: 10.2337/diabetes.52.11.2833.
7
Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort.纤维蛋白原是1型糖尿病肾病和外周血管疾病的标志物：糖尿病控制与并发症试验/糖尿病干预和并发症流行病学研究（DCCT/EDIC）队列中的血浆纤维蛋白原及纤维蛋白原基因多态性研究
Diabetes Care. 2003 May;26(5):1439-48. doi: 10.2337/diacare.26.5.1439.
8
Fibrinogen and its degradation products as thrombotic risk factors.纤维蛋白原及其降解产物作为血栓形成的危险因素。
Ann N Y Acad Sci. 2001;936:560-5. doi: 10.1111/j.1749-6632.2001.tb03544.x.
9
Association of fibrinogen with quantity of coronary artery calcification measured by electron beam computed tomography.纤维蛋白原与电子束计算机断层扫描测量的冠状动脉钙化量的关联。
Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2167-71. doi: 10.1161/01.atv.20.9.2167.
10
Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method.冠状动脉疾病：采用电子束CT容积法提高钙化评分的可重复性。
Radiology. 1998 Sep;208(3):807-14. doi: 10.1148/radiology.208.3.9722864.
Zotero 插件