University of Heidelberg, Inorganic Chemistry Institute, 69120 Heidelberg, Germany.
Bioorg Med Chem Lett. 2010 Feb 15;20(4):1445-7. doi: 10.1016/j.bmcl.2009.12.105. Epub 2010 Jan 4.
Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when the charge of the latter is low, and stability of the probe-heparin complex increases with increasing probe charge.
合成了带有 2、4、6 或 8 个铵基团的荧光苝二酰亚胺探针，并通过溶液荧光光谱法研究了它们与抗血栓药物肝素的结合。当后者的电荷较低时，肝素的多糖链结合更多的探针分子，并且探针-肝素配合物的稳定性随探针电荷的增加而增加。
