Department of Biology, Faculty of Sciences, University of Guilan, Namjoo Street, PO Box: 1914-41335, Rasht, Iran.
J Clin Neurosci. 2010 Mar;17(3):357-9. doi: 10.1016/j.jocn.2009.05.037. Epub 2010 Jan 15.
Acidic fibroblast growth factor (aFGF), also called FGF-1, which influences the proliferation and differentiation of various cell types in vitro, was originally isolated from neural tissue. It is released from the ependymal cells of the cerebral third ventricle into the cerebrospinal fluid (CSF). FGF-1 promotes the survival of neurons. Reactive astrocytes express FGF-1 in the brain of patients with Alzheimer's disease (AD). By comparing the CSF proteome of patients with AD and normal controls it might be possible to identify proteins that have a role in AD. Because CSF is in contact with the extracellular space of the brain, modifications in the brain biochemistry could be reflected in the CSF. The aim of this study was to determine concentrations of serum and CSF FGF-1 in patients with AD. This study consisted of 64 CSF samples, from patients with AD (n=32) and those without (normal controls) (n=32). The level of CSF and serum FGF-1 in patients with AD was higher than in patients without AD. We conclude that FGF-1 is a constant component of human serum and CSF and that FGF-1 may be involved in the pathophysiology of AD.
酸性成纤维细胞生长因子（aFGF），也称为 FGF-1，在体外影响各种细胞类型的增殖和分化，最初从神经组织中分离出来。它从第三脑室的室管膜细胞释放到脑脊液（CSF）中。FGF-1 促进神经元的存活。在阿尔茨海默病（AD）患者的大脑中，反应性星形胶质细胞表达 FGF-1。通过比较 AD 患者和正常对照组的 CSF 蛋白质组，可能可以确定在 AD 中起作用的蛋白质。因为 CSF 与大脑的细胞外空间接触，所以大脑生物化学的改变可以反映在 CSF 中。本研究的目的是确定 AD 患者血清和 CSF 中 FGF-1 的浓度。这项研究包括 64 例 CSF 样本，来自 AD 患者（n=32）和无 AD 患者（正常对照组）（n=32）。AD 患者的 CSF 和血清 FGF-1 水平高于无 AD 患者。我们得出结论，FGF-1 是人类血清和 CSF 的恒定成分，FGF-1 可能参与 AD 的病理生理学。
