Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh 160012, India.
Cancer Epidemiol. 2010 Feb;34(1):101-4. doi: 10.1016/j.canep.2009.12.015. Epub 2010 Jan 15.
In the recent past, adenocarcinoma has become the commonest histological type of lung cancer (LC) in the developed countries. The present study was conducted to assess the change in epidemiology of LC, if any, in North India.
Prospectively collected data on 250 newly diagnosed LC patients presenting to a tertiary care institute was analyzed. Results were compared with the previously published data from this center.
No significant differences were observed in the demographical, histological or smoking profiles of LC patients compared to those seen three decades earlier. The mean [standard deviation] age was 57.9 [+/-11.3] years (previously 54.3 years). Male to female ratio was 4.43:1 (previously 4.48:1; p=0.952) while the smoker to non-smoker ratio was 2.67:1 (previously 2.68:1; p=0.980). The commonest histological types were squamous cell (34.8%), adenocarcinoma (26.0%) and small cell (18.4%) while previously these were 34.3%, 25.9% and 20.3%, respectively; p=0.916. However, in the present study, significant differences were observed between smokers and non-smokers in relation to distribution of gender, histology and disease stage.
There has been no significant change in the epidemiology of LC in North India over the past three decades. An absence of change in the smoking pattern of the population could be a possible reason.
在最近的过去，腺癌已成为发达国家最常见的肺癌（LC）组织学类型。本研究旨在评估印度北部 LC 的流行病学是否发生变化。
前瞻性收集了一家三级医疗机构 250 例新诊断的 LC 患者的数据，并进行了分析。结果与该中心以前发表的数据进行了比较。
与三十年前相比，LC 患者的人口统计学、组织学或吸烟状况没有明显差异。平均（标准差）年龄为 57.9（+/-11.3）岁（以前为 54.3 岁）。男女比例为 4.43:1（以前为 4.48:1；p=0.952），吸烟者与非吸烟者的比例为 2.67:1（以前为 2.68:1；p=0.980）。最常见的组织学类型是鳞状细胞（34.8%）、腺癌（26.0%）和小细胞癌（18.4%），而以前这三种类型分别占 34.3%、25.9%和 20.3%；p=0.916。然而，在本研究中，吸烟与非吸烟者之间在性别、组织学和疾病分期方面的分布存在显著差异。
在过去的三十年中，印度北部 LC 的流行病学没有发生显著变化。人口吸烟模式没有变化可能是一个原因。
