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DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection.正常肝组织与不同病毒感染的肝细胞癌中的 DNA 甲基化变化。
Exp Mol Pathol. 2010 Apr;88(2):287-92. doi: 10.1016/j.yexmp.2010.01.002. Epub 2010 Jan 14.
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Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake.异常的 DNA 甲基化可区分乙型肝炎病毒和丙型肝炎病毒感染以及饮酒相关的肝细胞癌。
J Hepatol. 2011 Apr;54(4):705-15. doi: 10.1016/j.jhep.2010.07.027. Epub 2010 Sep 25.
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[Aberrant methylation of multiple genes and its clinical implication in hepatocellular carcinoma].[多种基因的异常甲基化及其在肝细胞癌中的临床意义]
Zhonghua Zhong Liu Za Zhi. 2008 Nov;30(11):831-6.
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Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma.鉴定丙型肝炎病毒相关肝细胞癌中优先甲基化的基因。
Cancer Sci. 2010 Jun;101(6):1501-10. doi: 10.1111/j.1349-7006.2010.01549.x. Epub 2010 Feb 27.
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p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival: A systematic meta-analysis (PRISMA).p16甲基化与肝细胞癌的发生、年龄、肝脏病毒感染相关，且p16表达提示预后不良：一项系统的荟萃分析（PRISMA）
Medicine (Baltimore). 2017 Sep;96(38):e8106. doi: 10.1097/MD.0000000000008106.
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Promoter hypermethylation of p14 (ARF) , RB, and INK4 gene family in hepatocellular carcinoma with hepatitis B virus infection.乙型肝炎病毒感染的肝细胞癌中p14（ARF）、RB和INK4基因家族的启动子高甲基化
Tumour Biol. 2014 Mar;35(3):2795-802. doi: 10.1007/s13277-013-1372-0. Epub 2013 Nov 20.
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microRNA-122 abundance in hepatocellular carcinoma and non-tumor liver tissue from Japanese patients with persistent HCV versus HBV infection.日本持续性丙型肝炎病毒（HCV）感染与乙型肝炎病毒（HBV）感染患者的肝细胞癌及非肿瘤肝组织中微小RNA-122的丰度
PLoS One. 2013 Oct 9;8(10):e76867. doi: 10.1371/journal.pone.0076867. eCollection 2013.
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Hepatitis virus infection affects DNA methylation in mice with humanized livers.肝炎病毒感染影响人源化肝脏小鼠的 DNA 甲基化。
Gastroenterology. 2014 Feb;146(2):562-72. doi: 10.1053/j.gastro.2013.10.056. Epub 2013 Oct 30.
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Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas.在乙型肝炎病毒相关肝细胞癌中，CpG岛DNA高甲基化导致GSTP1基因沉默。
Clin Cancer Res. 2002 Apr;8(4):1087-92.
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Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma.比较分析 HCV 阳性肝癌患者肿瘤组织和非肿瘤组织启动子甲基化和基因表达终点。
Mutat Res. 2010 Oct 13;692(1-2):26-33. doi: 10.1016/j.mrfmmm.2010.07.013. Epub 2010 Aug 22.
引用本文的文献
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Chronic Hepatitis C Infection Treated with Direct-Acting Antiviral Agents and Occurrence/Recurrence of Hepatocellular Carcinoma: Does It Still Matter?直接作用抗病毒药物治疗慢性丙型肝炎感染与肝细胞癌的发生/复发：这仍然重要吗？
Viruses. 2024 Dec 10;16(12):1899. doi: 10.3390/v16121899.
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Blood biomarkers of hepatocellular carcinoma: a critical review.肝细胞癌的血液生物标志物：一项批判性综述。
Front Cell Dev Biol. 2024 Nov 22;12:1489836. doi: 10.3389/fcell.2024.1489836. eCollection 2024.
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Measuring the differential expression of the major hypermethylated tumor suppressor genes in tissues of primary hepatocellular carcinoma.检测原发性肝细胞癌组织中主要高甲基化肿瘤抑制基因的差异表达。
J Genet Eng Biotechnol. 2024 Sep;22(3):100394. doi: 10.1016/j.jgeb.2024.100394. Epub 2024 Jun 5.
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Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection.重建调控性高甲基化网络，以控制丙型肝炎病毒感染期间肝细胞癌的发展。
J Integr Bioinform. 2023 Nov 20;20(3). doi: 10.1515/jib-2023-0013. eCollection 2023 Sep 1.
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Unraveling the Molecular Mechanisms Involved in HCV-Induced Carcinogenesis.解析 HCV 诱导致癌作用的分子机制。
Viruses. 2022 Dec 11;14(12):2762. doi: 10.3390/v14122762.
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Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma.乙肝病毒相关肝细胞癌患者血浆和外周血单个核细胞中细胞周期蛋白D2（CCND2）基因启动子甲基化及甲胎蛋白水平的检测
Med Sci Monit. 2020 Dec 15;26:e927444. doi: 10.12659/MSM.927444.
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Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma.鉴定RASSF1A启动子高甲基化作为肝细胞癌的生物标志物。
Cancer Cell Int. 2020 Nov 10;20(1):547. doi: 10.1186/s12935-020-01638-5.
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Identification of a Novel Eight-lncRNA Prognostic Signature for HBV-HCC and Analysis of Their Functions Based on Coexpression and ceRNA Networks.鉴定新型八长链非编码 RNA 预后标志物用于 HBV-HCC 并基于共表达和 ceRNA 网络分析其功能。
Biomed Res Int. 2020 Apr 14;2020:8765461. doi: 10.1155/2020/8765461. eCollection 2020.
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Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment.与慢性丙型肝炎病毒感染相关的肝细胞癌机制及直接抗病毒治疗的影响
J Hepatocell Carcinoma. 2020 Apr 15;7:45-76. doi: 10.2147/JHC.S221187. eCollection 2020.
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Association between SFRP promoter hypermethylation and different types of cancer: A systematic review and meta-analysis.分泌型卷曲相关蛋白（SFRP）启动子高甲基化与不同类型癌症之间的关联：一项系统评价和荟萃分析。
Oncol Lett. 2019 Oct;18(4):3481-3492. doi: 10.3892/ol.2019.10709. Epub 2019 Aug 2.
本文引用的文献
1
Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver.肝细胞癌、肝硬化和正常肝脏的启动子甲基化定量分析
Int J Cancer. 2008 Jun 15;122(12):2800-4. doi: 10.1002/ijc.23433.
2
Natural history of hepatitis-related hepatocellular carcinoma.肝炎相关肝细胞癌的自然史。
World J Gastroenterol. 2008 Mar 21;14(11):1652-6. doi: 10.3748/wjg.14.1652.
3
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.非小细胞肺癌患者肿瘤组织及配对正常组织中的DNA甲基化
Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):645-54. doi: 10.1158/1055-9965.EPI-07-2518.
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Epigenetics: differential DNA methylation in mammalian somatic tissues.表观遗传学：哺乳动物体细胞组织中的DNA甲基化差异
FEBS J. 2008 Apr;275(8):1617-23. doi: 10.1111/j.1742-4658.2008.06330.x. Epub 2008 Mar 7.
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Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma.衰老肝脏、慢性肝炎和肝细胞癌中多个肿瘤抑制基因的异常甲基化。
Hepatology. 2008 Mar;47(3):908-18. doi: 10.1002/hep.22110.
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Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis.肝细胞癌的表观遗传缺陷已在遗传性血色素沉着症患者的非肿瘤性肝细胞中被发现。
Hum Mol Genet. 2007 Jun 1;16(11):1335-42. doi: 10.1093/hmg/ddm082. Epub 2007 Apr 5.
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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.人类基因组中启动子DNA甲基化的分布、沉默潜能及进化影响
Nat Genet. 2007 Apr;39(4):457-66. doi: 10.1038/ng1990. Epub 2007 Mar 4.
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Analysis of tissue-specific differentially methylated regions (TDMs) in humans.人类组织特异性差异甲基化区域（TDMs）的分析。
Genomics. 2007 Mar;89(3):326-37. doi: 10.1016/j.ygeno.2006.11.006. Epub 2006 Dec 26.
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Hepatocellular carcinoma pathogenesis: from genes to environment.肝细胞癌的发病机制：从基因到环境
Nat Rev Cancer. 2006 Sep;6(9):674-87. doi: 10.1038/nrc1934.
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Viral hepatitis and liver cancer: the case of hepatitis C.病毒性肝炎与肝癌：丙型肝炎病例
Oncogene. 2006 Jun 26;25(27):3834-47. doi: 10.1038/sj.onc.1209562.
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