Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
J Chromatogr A. 2010 Feb 19;1217(8):1354-61. doi: 10.1016/j.chroma.2009.12.065. Epub 2010 Jan 4.
The intermittent SMB (I-SMB) process is a multi-column chromatographic process, which is a modification of the conventional SMB process, has been applied so far only in the sugar industry and is claimed to achieve higher productivity. In the I-SMB process the time interval between two port switches is divided in two sub-intervals, and only during the first the product streams are collected. The potential of the I-SMB technology is demonstrated in the case of the separation of a binary mixture subject to the linear isotherm by using both the equilibrium theory of chromatography and detailed simulations. It is shown that a I-SMB with only four columns can achieve much higher separation performance than a SMB unit with four columns.
间歇 SMB（I-SMB）工艺是一种多柱色谱工艺，是对传统 SMB 工艺的改进，迄今为止仅在制糖工业中得到应用，并声称可实现更高的生产力。在 I-SMB 工艺中，两次端口切换之间的时间间隔分为两个子间隔，并且仅在第一个子间隔期间收集产品流。通过使用色谱平衡理论和详细模拟，在分离受线性等温线限制的二元混合物的情况下，证明了 I-SMB 技术的潜力。结果表明，仅用四个柱的 I-SMB 可以比具有四个柱的 SMB 单元实现更高的分离性能。
