Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul 133-791, South Korea.
J Chromatogr A. 2012 Mar 23;1230:100-9. doi: 10.1016/j.chroma.2012.01.081. Epub 2012 Feb 4.
A three-zone simulated moving bed (SMB) chromatographic process for binary separation, which has been developed previously, was reported to have four ports that are located in the order of desorbent, extract, feed, and raffinate. To make a substantial improvement in the performance of such a three-zone SMB process, the strategy of rearranging the port locations was proposed in this study within a linear isotherm region. The core of the proposed strategy is to transfer the location of the extract port from its classical position (i.e., the position between zones I and II) to the zone III outlet. Simultaneously, the feed and raffinate ports are transferred backwards by one zone. Thus, the order of the proposed port locations follows the order of desorbent, feed, raffinate, and extract. The results from both equilibrium-theory analysis and detailed simulation proved that the proposed strategy was highly effective in improving the product purities or throughput of a three-zone SMB process. Furthermore, it was found that such advantage of the proposed strategy became greater as the difference between the adsorption affinities of the feed components was larger.
先前已报道过一种用于二元分离的三区域模拟移动床（SMB）色谱工艺，该工艺具有四个位于脱附剂、萃取物、进料和萃余物顺序的端口。为了实质性地改进这种三区域 SMB 工艺的性能，本研究提出了在线性等温区内重新排列端口位置的策略。所提出策略的核心是将萃取端口的位置从其经典位置（即区域 I 和区域 II 之间的位置）转移到区域 III 出口。同时，进料和萃余物端口向后移动一个区域。因此，所提出的端口位置顺序为脱附剂、进料、萃余物和萃取物。平衡理论分析和详细模拟的结果均证明，该策略在提高三区域 SMB 工艺的产品纯度或处理量方面非常有效。此外，还发现随着进料组分吸附亲和力之间的差异增大，所提出策略的优势变得更大。
