Rajendran Arvind, Paredes Galatea, Mazzotti Marco
Nanyang Technological University, School of Chemical and Biomedical Engineering, 62 Nanyang Drive, Singapore 637459, Singapore.
J Chromatogr A. 2009 Jan 23;1216(4):709-38. doi: 10.1016/j.chroma.2008.10.075. Epub 2008 Nov 1.
Simulated moving bed (SMB) chromatography, a continuous multi-column chromatographic process, has become one of the preferred techniques for the separation of the enantiomers of a chiral compound. Several active pharmaceutical ingredients, including blockbuster drugs, are manufactured using the SMB technology. Compared to single column preparative chromatography, SMB separations achieve higher productivity and purity, while reducing the solvent consumption. The SMB technology has found applications both at small and large scales. Design methods have been developed for robust operation and scale-up, using data obtained from analytical experiments. In the last few years, rapid developments have been made in the areas of design, improved process schemes, optimization and robust control. This review addresses these developments, as well as both the fundamentals of the SMB science and technology and some practical issues concerning the operation of SMB units. Particular emphasis is placed on the consolidation of the "triangle theory", a design tool that is used both in the academia and industry for the design of SMB processes.
模拟移动床（SMB）色谱法是一种连续的多柱色谱过程，已成为分离手性化合物对映体的首选技术之一。包括重磅炸弹药物在内的几种活性药物成分都是使用SMB技术生产的。与单柱制备色谱法相比，SMB分离可实现更高的生产率和纯度，同时减少溶剂消耗。SMB技术已在小规模和大规模应用中得到应用。利用从分析实验中获得的数据，已开发出用于稳健操作和放大的设计方法。在过去几年中，在设计、改进工艺方案、优化和稳健控制等领域取得了快速进展。本综述阐述了这些进展，以及SMB科学技术的基本原理和有关SMB装置操作的一些实际问题。特别强调了“三角形理论”的整合，这是一种在学术界和工业界都用于设计SMB过程的设计工具。
