Department of Clinical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, M20 4BX, United Kingdom.
Lung Cancer. 2010 May;68(2):129-36. doi: 10.1016/j.lungcan.2009.12.004. Epub 2010 Jan 15.
Mortality from lung cancer is increasing in patients > or = 70 years. Radiotherapy has an important role in the treatment of lung cancer for this group. Despite this, there have been few elderly specific trials of radiotherapy in lung cancer and current treatment is often based on evidence extrapolated from studies treating younger patients. This review of the literature examines the impact of radiotherapy for the radical and palliative treatment of non-small-cell and small-cell lung cancer, on survival, treatment-related toxicity and quality of life in the elderly. We also comment on the need for validated, practical geriatric screening and assessment tools to help predict toxicity to treatment.
肺癌患者的死亡率在>或=70 岁的患者中正在上升。对于这一人群，放射治疗在肺癌的治疗中具有重要作用。尽管如此，针对老年肺癌患者的放射治疗的专门试验却很少，目前的治疗方法通常是基于从治疗年轻患者的研究中推断出来的证据。本文对文献进行了回顾，以评估放射治疗对非小细胞肺癌和小细胞肺癌的根治性和姑息性治疗在生存、治疗相关毒性和老年患者生活质量方面的影响。我们还评论了需要经过验证的、实用的老年病筛选和评估工具，以帮助预测治疗毒性。
