Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.
DNA Repair (Amst). 2010 Mar 2;9(3):345-53. doi: 10.1016/j.dnarep.2009.12.008. Epub 2010 Jan 18.
The RecQ family of helicases are traditionally viewed as recombination factors, important for maintaining genome stability. RECQL5 is unique among these proteins in being associated with RNA polymerase II, the enzyme responsible for transcribing all protein-encoding genes in eukaryotes. Here, we describe the possible implications of recent studies and discuss models for RECQL5 function.
RecQ 解旋酶家族传统上被视为重组因子，对维持基因组稳定性很重要。在这些蛋白中，RECQL5 是唯一与 RNA 聚合酶 II 相关的蛋白，后者负责转录真核生物中所有编码蛋白的基因。在这里，我们描述了最近研究的可能意义，并讨论了 RECQL5 功能的模型。
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