Abbott Vascular, 359 Dudley Ferry Road, Mattaponi, VA 23110, USA.
Vet Pathol. 2010 Jan;47(1):58-76. doi: 10.1177/0300985809352978.
Coronary arterial disease (CAD) is the leading cause of death in the United States, the European Union, and Canada. Percutaneous coronary intervention (PCI) has revolutionized the treatment of CAD, and it is the advent of drug-eluting stent (DES) systems that has effectively allayed much of the challenge of restenosis that has plagued the success of PCI through its 30-year history. However, DES systems have not been a panacea: There yet remain the challenges associated with interventions involving bare metallic stents as well as newly arisen concerns related to the application of DES systems. To effectively address these novel and ongoing issues, animal models are relied on both to project the safety and efficacy of endovascular devices and to provide insight into the pathophysiology underlying the vascular response to injury and mechanisms of restenosis. In this review, preclinical models of restenosis are presented, and their application and limitation in the evaluation of device-based interventional technologies for the treatment of CAD are discussed.
冠状动脉疾病（CAD）是美国、欧盟和加拿大的主要死亡原因。经皮冠状动脉介入治疗（PCI）彻底改变了 CAD 的治疗方法，正是药物洗脱支架（DES）系统的出现，有效缓解了 PCI 30 年历史中一直困扰其成功的再狭窄挑战。然而，DES 系统并非万无一失：裸金属支架介入相关的挑战仍然存在，以及与 DES 系统应用相关的新出现的问题。为了有效解决这些新出现的问题，人们依赖于动物模型来预测血管内器械的安全性和有效性，并深入了解血管对损伤的病理生理反应以及再狭窄的机制。在这篇综述中，介绍了再狭窄的临床前模型，并讨论了它们在评估基于器械的介入治疗技术治疗 CAD 中的应用和局限性。
