Sledzińska Marta, Liberek Anna, Kamińska Barbara
Katedra i Klinika Pediatrii, Gastroenterologii, Hepatologii i zywienia Dzieci, Gdańskiego Uniwersytetu Medyczny, 80-803 Gdańsk.
Med Wieku Rozwoj. 2009 Oct-Dec;13(4):244-51.
The alarming increase of the prevalence of overweight and obesity observed recently in childhood and adolescence is one of the major contemporary paediatric problems. The excess of the body weight leads to many co-morbidities that may develop during childhood, for example: cardiovascular diseases, metabolic disorders (diabetes and insulin resistance), orthopaedic and psychiatric disorders. The last decade research showed that adipose tissue is not only a body lipid store but also an endocrine organ producing hormones named adipokines, including leptin, adiponectin, resistin, visfatin and many others. Adipokines play an important role in regulation of lipids and carbohydrates metabolism, appetite and energy expenditure. Recent data suggest that these hormones also have immunomodulating features and they that are involved in inflammatory processes leading to atherogenesis. This article presents current information about adipokines in childhood and adolescent obesity.
近年来在儿童和青少年中观察到的超重和肥胖患病率惊人上升，是当代主要的儿科问题之一。体重超标会导致许多可能在儿童期出现的合并症，例如：心血管疾病、代谢紊乱（糖尿病和胰岛素抵抗）、骨科和精神疾病。过去十年的研究表明，脂肪组织不仅是身体的脂质储存库，还是一个分泌名为脂肪因子的激素的内分泌器官，包括瘦素、脂联素、抵抗素、内脂素等等。脂肪因子在脂质和碳水化合物代谢、食欲和能量消耗的调节中起重要作用。最近的数据表明，这些激素还具有免疫调节功能，并参与导致动脉粥样硬化的炎症过程。本文介绍了有关儿童和青少年肥胖中脂肪因子的当前信息。
