Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON Canada.
Cell Cycle. 2010 Feb 1;9(3):506-11. doi: 10.4161/cc.9.3.10552.
A common environment for the Hedgehog (Subfamily: erinaceinae) is a row of shrubs and trees often used on farms for enclosing or separating fields, called a hedgerow. Maintenance of a continuous shrub border is important for shielding crops from weather damage, but also provides an ideal protective habitat for the hedgehog. Similar to its mammalian counterpart, the Hedgehog (Hh) signalling pathway requires a controlled environment to regulate proper functioning of the cell. When allowed to run wild, constitutive activation of the Hh pathway results in tumorigenesis in different tissues types, including brain, skin and cartilage. With an additional loss of p53 tumor suppressor activity, an increase in tumor incidence, size and metastasis have been observed. p53 has a number of functions that can suppress tumor formation and growth in most, if not all Hh-related cancers, such as the inhibition of cell cycle progression and cell survival. Furthermore, increasing evidence of an interaction between p53 and Hedgehog signalling pathways suggests a critical role for the tumor suppressor activity of p53 in "protecting the hedgerow".
刺猬（亚科：猬科）的常见环境是一排灌木和乔木，这些树木通常用于农场围封或分隔田地，称为树篱。保持连续的灌木边界对于保护作物免受天气损害很重要，但也为刺猬提供了理想的保护栖息地。与哺乳动物类似，刺猬（Hh）信号通路需要一个受控的环境来调节细胞的正常功能。当 Hh 通路不受控制地激活时，会导致不同组织类型发生肿瘤，包括脑、皮肤和软骨。如果再加上 p53 肿瘤抑制因子活性的丧失，就会观察到肿瘤发生率、大小和转移的增加。p53 具有多种功能，可以抑制大多数（如果不是全部）与 Hh 相关的癌症中的肿瘤形成和生长，例如抑制细胞周期进程和细胞存活。此外，越来越多的证据表明 p53 和 Hedgehog 信号通路之间存在相互作用，这表明 p53 的肿瘤抑制活性在“保护树篱”中起着关键作用。
